Role of Computational Fluid Dynamics for Predicting Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage: Study Protocol for a Multicenter Prospective Study

被引：1

作者：

Shiba, Masato ^{[1
]}

Ishida, Fujimaro ^{[2
]}

Miya, Fumitaka ^{[3
]}

Araki, Tomohiro ^{[4
]}

Mase, Mitsuhito ^{[5
]}

Kurita, Hiroki ^{[6
]}

Kasuya, Hidetoshi ^{[7
]}

Yamamoto, Takuji ^{[8
]}

Kato, Yoko ^{[9
]}

Iwabuchi, Satoshi ^{[10
]}

Suzuki, Hidenori ^{[1
]}

机构：

[1] Mie Univ, Grad Sch Med, Dept Neurosurg, Tsu, Mie, Japan

[2] Mie Cent Med Ctr, Dept Neurosurg, Tsu, Mie, Japan

[3] Ise Red Cross Hosp, Dept Neurosurg, Ise, Japan

[4] Suzuka Kaisei Hosp, Dept Neurosurg, Suzuka, Japan

[5] Nagoya City Univ, Grad Sch Med, Dept Neurosurg, Nagoya, Aichi, Japan

[6] Saitama Med Univ, Int Med Ctr, Dept Cerebrovasc Surg, Saitama, Japan

[7] Tokyo Womens Med Univ, Med Ctr East, Dept Neurosurg, Tokyo, Japan

[8] Juntendo Univ, Shizuoka Hosp, Dept Neurosurg, Shizuoka, Japan

[9] Fujita Hlth Univ, Banbuntane Hotokukai Hosp, Dept Neurosurg, Nagoya, Aichi, Japan

[10] Toho Univ, Med Ctr, Ohashi Hosp, Dept Neurosurg, Tokyo, Japan

来源：

SUBARACHNOID HEMORRHAGE: NEUROLOGICAL CARE AND PROTECTION | 2020年 / 127卷

基金：

日本学术振兴会;

关键词：

Subarachnoid hemorrhage; Delayed cerebral ischemia; Cerebral aneurysm; Computational fluid dynamics; Computed tomography angiography;

D O I：

10.1007/978-3-030-04615-6_24

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background: Delayed cerebral ischemia (DCI) is a significant cause of morbidity and mortality after aneurysmal subarachnoid hemorrhage (SAH). Recently, we reported the possibility that computational fluid dynamics (CFD) could predict DCI in terms of the cross-sectional area and flow velocity of the ipsilateral extracranial internal carotid and distal parent arteries in a single-center retrospective study. Methods: This is a multicenter, prospective, cohort study. Patients with aneurysmal SAH will undergo CFD analyses using preoperative three-dimensional computed tomography angiography, and we will investigate hemodynamic features of cerebral arteries in an acute stage of SAH. Primary outcome measures will be CFD features in patients with subsequent occurrence of DCI. Secondary outcome measures will be CFD features in patients with subsequent occurrence of cerebral vasospasm and cerebral infarction and the relationships with eventual modified Rankin scale score at 3 months. Conclusions: The present protocol for a multicenter prospective study is expected to provide a novel diagnostic method to predict DCI before aneurysmal obliteration in an acute stage of SAH.

引用

页码：161 / 164

页数：4