Influence on hazelnut oil administration on peroxidation status of erythrocytes and apolipoprotein B 100-containing lipoproteins in rabbits fed on a high cholesterol diet

被引：7

作者：

Balkan, J ^{[1
]}

Hatipoglu, A ^{[1
]}

Aykaç-Toker, G ^{[1
]}

Uysal, M ^{[1
]}

机构：

[1] Istanbul Univ, Istanbul Fac Med, Dept Biochem, TR-34093 Istanbul, Turkey

来源：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 2003年 / 51卷 / 13期

关键词：

hazelnut oil; high cholesterol diet; lipid peroxidation; erythrocytes; apo B-containing lipoproteins; rabbit;

D O I：

10.1021/jf0300238

中图分类号：

S [农业科学];

学科分类号：

09 ;

摘要：

Hazelnut oil (HO) is rich in monounsaturated fatty acids (MUFA). The effect of a high cholesterol (HC) diet with and without HO on lipids and lipid peroxide levels in plasma, apolipoprotein B 100-containing lipoproteins (VLDL + LDL), and erythrocytes as well as hematological data was investigated in rabbits. A HC diet caused significant increases in lipid peroxide levels in plasma and apo B-containing lipoproteins together with histopathological atherosclerotic findings in aorta. In addition, this diet resulted in hemolytic anemia associated with increased endogenous diene conjugate (DC) levels, but H2O2-induced malondialdehyde (MIDA) levels remained unchanged in erythrocytes. HO supplementation reduced lipid peroxide levels in plasma and apolipoprotein B 100-containing lipoproteins as well as aortic atherosclerotic lesions in rabbits fed an HC diet without any decreasing effect on lipid levels. In addition, HO was found to reduce hemolytic anemia together with significant decreases in DC and H2O2-induced MDA levels.

引用

页码：3905 / 3909

页数：5

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