Immunity unmasks APOL1 in collapsing glomerulopathy

被引：6

作者：

McNicholas, Bairbre A. ^{[1
,2
]}

Nelson, Peter J. ^{[1
,2
]}

机构：

[1] Univ Washington, Div Nephrol, Seattle, WA 98195 USA

[2] Univ Washington, Kidney Res Inst, Seattle, WA 98195 USA

来源：

KIDNEY INTERNATIONAL | 2015年 / 87卷 / 02期

关键词：

cytokines; glomerulus; inflammation; podocyte; renal pathology; signaling; KIDNEY-DISEASE; ALPHA;

D O I：

10.1038/ki.2014.325

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Collapsing glomerulopathy predominantly afflicts patients of African ancestry, often first presenting after the immune system is engaged by another disorder. Nichols et al. now show that collateral induction of pathogenic APOL1 allelic variants in podocytes by the ongoing immune response may be the long-sought-after explanation for the development of collapsing glomerulopathy in these patients.

引用

页码：270 / 272

页数：3

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