Immunity unmasks APOL1 in collapsing glomerulopathy

被引：6
|
作者：
McNicholas, Bairbre A. [1 ,2 ]
Nelson, Peter J. [1 ,2 ]
机构：
[1] Univ Washington, Div Nephrol, Seattle, WA 98195 USA
[2] Univ Washington, Kidney Res Inst, Seattle, WA 98195 USA
来源：
KIDNEY INTERNATIONAL | 2015年 / 87卷 / 02期
关键词：
cytokines; glomerulus; inflammation; podocyte; renal pathology; signaling; KIDNEY-DISEASE; ALPHA;
D O I：
10.1038/ki.2014.325
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Collapsing glomerulopathy predominantly afflicts patients of African ancestry, often first presenting after the immune system is engaged by another disorder. Nichols et al. now show that collateral induction of pathogenic APOL1 allelic variants in podocytes by the ongoing immune response may be the long-sought-after explanation for the development of collapsing glomerulopathy in these patients.
引用
收藏
页码：270 / 272
页数：3
相关论文
共 50 条
  • [1] Editing of APOL1 mRNA reduces APOL1 expression and activation of innate immunity
    Karttunen, Heidi
    Ross, Michael J.
    KIDNEY INTERNATIONAL, 2023, 104 (02)
  • [2] Obesity-related glomerulopathy in the presence of APOL1 risk alleles
    Imbert, Ronald Valdez
    Seng, Nang San Hti Lar
    Stokes, Michael B.
    Jim, Belinda
    BMJ CASE REPORTS, 2022, 15 (08)
  • [3] Gene of the month: APOL1
    Raghubeer, Shanel
    Pillay, Tahir S.
    Matsha, Tandi Edith
    JOURNAL OF CLINICAL PATHOLOGY, 2020, 73 (08) : 441 - 443
  • [4] Collapsing glomerulopathy in a young woman with APOL1 risk alleles following acute parvovirus B19 infection: a case report investigation
    Besse, Whitney
    Mansour, Sherry
    Jatwani, Karan
    Nast, Cynthia C.
    Brewster, Ursula C.
    BMC NEPHROLOGY, 2016, 17
  • [5] The Cell Biology of APOL1
    O'Toole, John F.
    Bruggeman, Leslie A.
    Madhavan, Sethu
    Sedor, John R.
    SEMINARS IN NEPHROLOGY, 2017, 37 (06) : 538 - 545
  • [6] APOL1-mediated and Mendelian forms of "heretofore" idiopathic collapsing glomerulopathy lessons from Brazil
    Palmer, Nicholette D.
    Freedman, Barry I.
    KIDNEY INTERNATIONAL, 2024, 105 (03)
  • [7] The metabolic effects of APOL1 in humans
    Adeva-Andany, Maria M.
    Funcasta-Calderon, Raquel
    Fernandez-Fernandez, Carlos
    Ameneiros-Rodriguez, Eva
    Vila-Altesor, Matilde
    Castro-Quintela, Elvira
    PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 2023, 475 (08): : 911 - 932
  • [8] APOL1 Modulates Renin-Angiotensin System
    Kumar, Vinod
    Kaur, Prabhjot
    Ayasolla, Kameshwar
    Jha, Alok
    Wiqas, Amen
    Vashistha, Himanshu
    Saleem, Moin A.
    Popik, Waldemar
    Malhotra, Ashwani
    Gebeshuber, Christoph A.
    Skorecki, Karl
    Singhal, Pravin C.
    BIOMOLECULES, 2024, 14 (12)
  • [9] APOL1 and kidney cell function
    Kumar, Vinod
    Singhal, Pravin C.
    AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2019, 317 (02) : F463 - F477
  • [10] Hypoxia hits APOL1 in the kidney
    Grampp, Steffen
    Krueger, Rene
    Lauer, Victoria
    Uebel, Sebastian
    Knaup, Karl X.
    Naas, Julia
    Hoeffken, Verena
    Weide, Thomas
    Schiffer, Mario
    Naas, Stephanie
    Schoedel, Johannes
    KIDNEY INTERNATIONAL, 2023, 104 (01) : 53 - 60
12345