Benzopyran selective estrogen receptor modulators (SERMs): Pharmacological effects and structural correlation with raloxifene

被引：23

作者：

Grese, TA

Sluka, JP

Bryant, HU

Cole, HW

Kim, JR

Magee, DE

Rowley, ER

Sato, M

机构：

[1] Lilly Research Laboratories, Eli Lilly and Company, Indianapolis

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 07期

关键词：

D O I：

10.1016/0960-894X(96)00141-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Several 2,3-diarylbenzopyrans have been evaluated in an ovariectomized rat model and found to exhibit tissue selective estrogen agonist activity on bone and serum lipid parameters. A structural model that accounts for the pharmacological similarity of these benzopyrans and the benzothiophene SERM, raloxifene, is proposed. Copyright (C) 1996 Elsevier Science Ltd

引用

收藏

页码：903 / 908

页数：6

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