Armochaeglobines A and B, Two New Indole-Based Alkaloids from the Arthropod-Derived Fungus Chaetomium globosum

被引：60

作者：

Chen, Chunmei ^{[1
]}

Zhu, Hucheng ^{[1
]}

Li, Xiao-Nian ^{[2
]}

Yang, Jing ^{[2
,3
]}

Wang, Jianping ^{[1
]}

Li, Gentao ^{[2
]}

Li, Yan ^{[2
]}

Tong, Qingyi ^{[1
]}

Yao, Guangmin ^{[1
]}

Luo, Zengwei ^{[1
]}

Xue, Yongbo ^{[1
]}

Zhang, Yonghui ^{[1
]}

机构：

[1] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Peoples R China

[2] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China

[3] Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China

来源：

ORGANIC LETTERS | 2015年 / 17卷 / 03期

基金：

中国国家自然科学基金;

关键词：

CYTOTOXIC CYTOCHALASANS; CHAETOGLOBOSIN; CELLS;

D O I：

10.1021/ol503666b

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Armochaeglobines A (1) and B (2), two indole-based cytochalasan alkaloids with new carbon skeletons, were obtained from the fungus Chaetomium globosum TW1-1, which was first isolated from the arthropod Armadillidium vulgare. Their structures were elucidated by extensive spectroscopic analyses, ECD calculation, and single-crystal X-ray diffraction analysis. Interestingly, compound 1 featured a unique tetracyclic 5/6/7/5 fused ring system and 2 possessed a rare 12-membered carbon scaffold.

引用

页码：644 / 647

页数：4

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