Periinfarct rewiring supports recovery after primary motor cortex stroke

被引:7
作者
van Assche, Mitsouko [1 ]
Dirren, Elisabeth [1 ]
Bourgeois, Alexia [1 ,2 ]
Kleinschmidt, Andreas [1 ]
Richiardi, Jonas [3 ,4 ]
Carrera, Emmanuel [1 ]
机构
[1] Univ Hosp, Dept Clin Neurosci, Stroke Res Grp, Geneva, Switzerland
[2] Univ Geneva, Lab Cognit Neurorehabilitat, Fac Med, Geneva, Switzerland
[3] Univ Lausanne Hosp, Dept Radiol, Lausanne, Switzerland
[4] Univ Lausanne, Lausanne, Switzerland
基金
瑞士国家科学基金会;
关键词
Functional connectivity; network; primary motor cortex; recovery; stroke; FUNCTIONAL CONNECTIVITY; NETWORK CONNECTIVITY; BRAIN STATES; FMRI; REORGANIZATION; MOVEMENT; ACTIVATION; DEFICITS;
D O I
10.1177/0271678X211002968
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
After stroke restricted to the primary motor cortex (M1), it is uncertain whether network reorganization associated with recovery involves the periinfarct or more remote regions. We studied 16 patients with focal M1 stroke and hand paresis. Motor function and resting-state MRI functional connectivity (FC) were assessed at three time points: acute (<10 days), early subacute (3 weeks), and late subacute (3 months). FC correlates of recovery were investigated at three spatial scales, (i) ipsilesional non-infarcted M1, (ii) core motor network (M1, premotor cortex (PMC), supplementary motor area (SMA), and primary somatosensory cortex), and (iii) extended motor network including all regions structurally connected to the upper limb representation of M1. Hand dexterity was impaired only in the acute phase (P = 0.036). At a small spatial scale, clinical recovery was more frequently associated with connections involving ipsilesional non-infarcted M1 (Odds Ratio = 6.29; P = 0.036). At a larger scale, recovery correlated with increased FC strength in the core network compared to the extended motor network (rho = 0.71;P = 0.006). These results suggest that FC changes associated with motor improvement involve the perilesional M1 and do not extend beyond the core motor network. Core motor regions, and more specifically ipsilesional non-infarcted M1, could hence become primary targets for restorative therapies.
引用
收藏
页码:2174 / 2184
页数:11
相关论文
共 50 条
[41]   Altered microstructure of the contralesional ventral premotor cortex and motor output after stroke [J].
Wrobel, Pawel P. ;
Guder, Stephanie ;
Feldheim, Jan F. ;
Perez, Jose A. Graterol ;
Frey, Benedikt M. ;
Choe, Chi-un ;
Boenstrup, Marlene ;
Cheng, Bastian ;
Rathi, Yogesh ;
Pasternak, Ofer ;
Thomalla, Goetz ;
Gerloff, Christian ;
Shenton, Martha E. ;
Schulz, Robert .
BRAIN COMMUNICATIONS, 2023, 5 (03)
[42]   Interhemispheric connectivity of primary sensory cortex is associated with motor impairment after stroke [J].
Frias, Ilse ;
Starrs, Faryn ;
Gisiger, Thomas ;
Minuk, Jeffrey ;
Thiel, Alexander ;
Paquette, Caroline .
SCIENTIFIC REPORTS, 2018, 8
[43]   "Remind-to-Move" Treatment Enhanced Activation of the Primary Motor Cortex in Patients with Stroke [J].
Bai, Zhongfei ;
Fong, Kenneth N. K. .
BRAIN TOPOGRAPHY, 2020, 33 (02) :275-283
[44]   Developmental Remodelling of the Motor Cortex in Hemiparetic Children With Perinatal Stroke [J].
Baker, Kayla ;
Carlson, Helen L. ;
Zewdie, Ephrem ;
Kirton, Adam .
PEDIATRIC NEUROLOGY, 2020, 112 :34-43
[45]   The structural connectome and motor recovery after stroke: predicting natural recovery [J].
Koch, Philipp J. ;
Park, Chang-Hyun ;
Girard, Gabriel ;
Beanato, Elena ;
Egger, Philip ;
Evangelista, Giorgia Giulia ;
Lee, Jungsoo ;
Wessel, Maximilian J. ;
Morishita, Takuya ;
Koch, Giacomo ;
Thiran, Jean-Philippe ;
Guggisberg, Adrian G. ;
Rosso, Charlotte ;
Kim, Yun-Hee ;
Hummel, Friedhelm C. .
BRAIN, 2021, 144 :2107-2119
[46]   Plasticity of the human motor cortex and recovery from stroke [J].
Hallett, M .
BRAIN RESEARCH REVIEWS, 2001, 36 (2-3) :169-174
[47]   Motor Cortex Plasticity Predicts Recovery in Acute Stroke [J].
Di Lazzaro, Vincenzo ;
Profice, P. ;
Pilato, F. ;
Capone, F. ;
Ranieri, F. ;
Pasqualetti, P. ;
Colosimo, C. ;
Pravata, E. ;
Cianfoni, A. ;
Dileone, M. .
CEREBRAL CORTEX, 2010, 20 (07) :1523-1528
[48]   Motor stroke recovery after tDCS: a systematic review [J].
Orru, Graziella ;
Conversano, Ciro ;
Hitchcott, Paul Kenneth ;
Gemignani, Angelo .
REVIEWS IN THE NEUROSCIENCES, 2020, 31 (02) :201-218
[49]   Changes in motor system function and recovery after stroke [J].
Cramer, SC .
RESTORATIVE NEUROLOGY AND NEUROSCIENCE, 2004, 22 (3-5) :231-238
[50]   Driving Motor Recovery After Stroke [J].
Richards, Lorie ;
Hanson, Carolyn ;
Wellborn, Melinda ;
Sethi, Amit .
TOPICS IN STROKE REHABILITATION, 2008, 15 (05) :397-411