Differences in Brain Morphology between Hydrocephalus Ex Vacuo and Idiopathic Normal Pressure Hydrocephalus

被引：8

作者：

Kim, Minkyung ^{[1
]}

Park, Sun-Won ^{[2
,3
]}

Lee, Jun-Young ^{[4
,5
]}

Kim, Hongrae ^{[4
,5
]}

Rhim, Jung Hyo ^{[2
]}

Park, Soowon ^{[6
]}

Lee, Jee-Young ^{[7
]}

Son, Hwancheol ^{[5
,8
]}

Kim, Yu Kyeong ^{[9
]}

Lee, Sang Hyung ^{[5
,10
]}

机构：

[1] Seoul Natl Univ, Coll Med, Seoul, South Korea

[2] SMG SNU Boramae Med Ctr, Dept Radiol, Seoul, South Korea

[3] Seoul Natl Univ, Dept Radiol, Coll Med, Seoul, South Korea

[4] Seoul Natl Univ, Dept Psychiat, Coll Med, 20 Boramae Ro 5 Gil, Seoul 07061, South Korea

[5] SMG SNU Boramae Med Ctr, 20 Boramae Ro 5 Gil, Seoul 07061, South Korea

[6] Kyonggi Univ, Coll Liberal Arts & Interdisciplinary Studies, Dept Teacher Educ, Suwon, South Korea

[7] SMG SNU Boramae Med Ctr, Dept Neurol, Seoul, South Korea

[8] Seoul Natl Univ, Dept Urol, Coll Med, Seoul, South Korea

[9] SMG SNU Boramae Med Ctr, Dept Nucl Med, Seoul, South Korea

[10] Seoul Natl Univ, Dept Neurosurg, Coll Med, 20 Boramae Ro 5 Gil, Seoul 07061, South Korea

来源：

PSYCHIATRY INVESTIGATION | 2021年 / 18卷 / 07期

关键词：

Normal pressure hydrocephalus; Dementia; Hydrocephalus ex vacuo; Alzheimer's disease; Magnetic resonance imaging; MAGNETIC-RESONANCE; ALZHEIMERS-DISEASE; CALLOSAL ANGLE; EVANS INDEX; DIAGNOSIS; MRI; DEMENTIA; FISSURES; LESIONS;

D O I：

10.30773/pi.2020.0352

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Objective The distinction between idiopathic normal pressure hydrocephalus (iNPH) and hydrocephalus ex vacuo caused by ence-phalic volume loss remains to be established. This study aims to investigate radiological parameters as clinically useful tools to discrimi-nate iNPH from hydrocephalus ex vacuo caused by Alzheimer's disease (AD). Methods A total of 54 patients with ventriculomegaly (iNPH, 25; hydrocephalus ex vacuo, 29) were recruited in this study. Consequent-ly, nine radiological parameters were compared between iNPH and hydrocephalus ex vacuo using magnetic resonance imaging (MRI). Results A small callosal angle (CA), the Sylvian fissure dilatation, and absence of narrowing of superior parietal sulci discriminated the iNPH group from the hydrocephalus ex vacuo group (p<0.05). The final binary logistic regression model included narrowing of su-perior parietal sulci, degrees of the CA, and height of the Sylvian fissure after controlling for age and global Clinical Dementia Rating (CDR). The composite score made from these three indicators (narrowing of superior parietal sulci, degrees of the CA, and height of the Sylvian fissure) was statistically different between iNPH and hydrocephalus ex vacuo. Conclusion The narrowing of the CA, dilatation of the Sylvain fissure, and narrowing of superior parietal sulci may be used as radio-logical key indices and noninvasive tools for the differential diagnosis of iNPH from hydrocephalus ex vacuo.

引用

页码：628 / 635

页数：8

共 34 条

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