ONE-POT SYNTHESIS OF ISOINDOLINONES VIA THREE-COMPONENT MANNICH/LACTAMIZATION CASCADE REACTION

被引：14

作者：

Zhang, Haoyi ^{[2
]}

Leng, Yixin ^{[2
]}

Liu, Wenjing ^{[2
]}

Duan, Wenhu ^{[1
,2
]}

机构：

[1] Chinese Acad Sci, Dept Med Chem, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China

[2] E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China

来源：

SYNTHETIC COMMUNICATIONS | 2012年 / 42卷 / 08期

关键词：

Cascade reaction; isoindolinone; lactamization; Mannich reaction; three-component; HIV-1; REVERSE-TRANSCRIPTASE; PROTEIN-PROTEIN INTERACTION; MANNICH REACTION; SOLVENT-FREE; INHIBITORS; DERIVATIVES; RECEPTOR; PAGOCLONE; KINASE; 3-ALKYL-1-ISOINDOLINONES;

D O I：

10.1080/00397911.2010.535948

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient synthesis of 3-substituted 2,3-dihydroisoindolin-1-ones was achieved with good yields (up to 88%). The process features broad substrate scope, high efficiency, and simplicity, using an one-pot, three-component Mannich/lactamization cascade reaction in the absence or presence of p-toluenesulfonic acid.

引用

页码：1115 / 1127

页数：13