ONE-POT SYNTHESIS OF ISOINDOLINONES VIA THREE-COMPONENT MANNICH/LACTAMIZATION CASCADE REACTION

被引：14
作者：
Zhang, Haoyi [2 ]
Leng, Yixin [2 ]
Liu, Wenjing [2 ]
Duan, Wenhu [1 ,2 ]
机构：
[1] Chinese Acad Sci, Dept Med Chem, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
[2] E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China
来源：
SYNTHETIC COMMUNICATIONS | 2012年 / 42卷 / 08期
关键词：
Cascade reaction; isoindolinone; lactamization; Mannich reaction; three-component; HIV-1; REVERSE-TRANSCRIPTASE; PROTEIN-PROTEIN INTERACTION; MANNICH REACTION; SOLVENT-FREE; INHIBITORS; DERIVATIVES; RECEPTOR; PAGOCLONE; KINASE; 3-ALKYL-1-ISOINDOLINONES;
D O I：
10.1080/00397911.2010.535948
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient synthesis of 3-substituted 2,3-dihydroisoindolin-1-ones was achieved with good yields (up to 88%). The process features broad substrate scope, high efficiency, and simplicity, using an one-pot, three-component Mannich/lactamization cascade reaction in the absence or presence of p-toluenesulfonic acid.
引用
收藏
页码：1115 / 1127
页数：13
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