Copper- and Nickel-Catalyzed Cross-Coupling Reaction of Monofluoroalkenes with Tertiary, Secondary, and Primary Alkyl and Aryl Grignard Reagents

被引：30

作者：

Shi, Hongyan ^{[1
]}

Dai, Wenpeng ^{[1
]}

Wang, Biyun ^{[1
]}

Cao, Song ^{[1
,2
]}

机构：

[1] ECUST, Shanghai Key Lab Chem Biol, Sch Pharm, Shanghai 200237, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Organofluorine Chem, Shanghai 200032, Peoples R China

来源：

ORGANOMETALLICS | 2018年 / 37卷 / 03期

基金：

中国国家自然科学基金;

关键词：

C-F BOND; ONE-POT SYNTHESIS; GEM-DIFLUOROALKENES; 2-FLUOROALLYLIC ACETATES; CARBONYL OLEFINATION; VINYLIC FLUORINES; ACTIVATION; DERIVATIVES; CYCLIZATION; ACCESS;

D O I：

10.1021/acs.organomet.7b00859

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A highly efficient cross-coupling reaction of monofluoroalkenes with tertiary, secondary, and primary alkyl and aryl Grignard reagents in the presence of a catalytic amount of copper or nickel catalyst, respectively, has been developed. The reactions proceeded smoothly at room temperature, providing (E)-alkene isomers in moderate to high yields. Plausible mechanisms of the Ni-catalyzed coupling reaction of monofluoroalkene with Grignard reagents are suggested.

引用

页码：459 / 463

页数：5

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