Neuroprotective effects of Sophora secundiflora, Sophora tomentosa leaves and formononetin on scopolamine-induced dementia

被引：38

作者：

Aly, Shaza H. ^{[1
]}

Elissawy, Ahmed M. ^{[2
,3
]}

Fayez, Ahmed M. ^{[4
]}

Eldahshan, Omayma A. ^{[2
,3
]}

Elshanawany, Mohamed A. ^{[1
]}

Singab, Abdel Nasser B. ^{[2
,3
]}

机构：

[1] Badr Univ Cairo, Fac Pharm, Dept Pharmacognosy, Cairo, Egypt

[2] Ain Shams Univ, Fac Pharm, Dept Pharmacognosy, Cairo, Egypt

[3] Ain Shams Univ, Ctr Drug Discovery Res & Dev, Cairo, Egypt

[4] October Univ Modern Sci & Arts, Fac Pharm, Dept Pharmacol, Giza, Egypt

来源：

NATURAL PRODUCT RESEARCH | 2021年 / 35卷 / 24期

关键词：

Sophora; formononetin; scopolamine; neuroprotective; flavonoids; LC/MS; FLAVONOIDS;

D O I：

10.1080/14786419.2020.1795853

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Five flavonoids were isolated from the ethyl acetate fraction of leaves ofSophora secundiflora; formononetin(1), 5-hydroxy-4'-methoxyflavone(2), genistein(3), 5-hydroxy-8-(1-hydroxy-1-methyl-ethyl)-2-(4-hydroxyphenyl)-4H-furo-[2, 3-h]-chromen-4-one(4)and ononin(5). Additionally, LC-ESI-MS/MS analysis of the ethyl acetate fraction ofS. secundifloraleaves had led to tentative identification of eighteen compounds. Formononetin,S. tomentosaandS. secundifloraleaves methanolic extract were evaluatedin vivofor their neuroprotective activity where formononetin andS. tomentosashowed promising neuroprotective activity with reduction in acetylcholine esterase (AchE) enzyme activity and elevation of acetylcholine (Ach) and glutathione(GSH) brain levels and attenuation of dopamine (DA), nor-adrenaline (NA) and malonedialdehyde (MDA) brain level significantly, HoweverS. secundifloraleaves methanolic extract didn't attenuate the AchE enzyme activity, DA and NA brain levels. [GRAPHICS]

引用

页码：5848 / 5852

页数：5

共 26 条

[1]

Adeneye A. A., 2009, Biology and Medicine, V1, P1

[2]

Aly S., 2019, TAECKHOLMIA, V39, P103, DOI [10.21608/taec.2020.20572.1010, DOI 10.21608/TAEC.2020.20572.1010]

[3] The pharmacology of the genus Sophora (Fabaceae): An updated review [J].

Aly, Shaza H. ;

Elissawy, Ahmed M. ;

Eldahshan, Omayma A. ;

Elshanawany, Mohamed A. ;

Efferth, Thomas ;

Singab, Abdel Nasser B. .

PHYTOMEDICINE, 2019, 64

[4] New norditerpenoid alkaloids from Aconitum falconeri [J].

Atta-ur-Rahman ;

Fatima, N ;

Akhtar, F ;

Choudhary, MI ;

Khalid, A .

JOURNAL OF NATURAL PRODUCTS, 2000, 63 (10) :1393-1395

[5] Flavones from callus tissue of Iris ensata [J].

Boltenkov, EV ;

Rybin, VG ;

Zarembo, EV .

CHEMISTRY OF NATURAL COMPOUNDS, 2005, 41 (05) :539-541

[6] Licochalcone B, a chalcone derivative from Glycyrrhiza inflata, as a multifunctional agent for the treatment of Alzheimer's disease [J].

Cao, Yingying ;

Xu, Wenxing ;

Huang, Yiyou ;

Zeng, Xing .

NATURAL PRODUCT RESEARCH, 2020, 34 (05) :736-739

[7] Sophora Tomentosa Extract Prevents MPTP-Induced Parkinsonism in C57BL/6 Mice Via the Inhibition of GSK-3 Phosphorylation and Oxidative Stress [J].

Chang, Hung-Chi ;

Liu, Keng-Fan ;

Teng, Chia-Jen ;

Lai, Shu-Chen ;

Yang, Shu-Er ;

Ching, Hui ;

Wu, Chi-Rei .

NUTRIENTS, 2019, 11 (02)

[8] REDUCED DOPAMINE-BETA-HYDROXYLASE ACTIVITY IN ALZHEIMERS-DISEASE [J].

CROSS, AJ ;

CROW, TJ ;

PERRY, EK ;

PERRY, RH ;

BLESSED, G ;

TOMLINSON, BE .

BRITISH MEDICAL JOURNAL, 1981, 282 (6258) :93-94

[9]

de Arruda VLV, 2006, BIOTEMAS, V19, P41

[10] Agathisflavone isolated from Schinus polygamus (Cav.) Cabrera leaves prevents scopolamine-induced memory impairment and brain oxidative stress in zebrafish (Danio rerio) [J].

Dumitru, Gabriela ;

El-Nashar, Heba A. S. ;

Mostafa, Nada M. ;

Eldahshan, Omayma A. ;

Boiangiu, Razvan Stefan ;

Todirascu-Ciornea, Elena ;

Hritcu, Lucian ;

Singab, Abdel Nasser B. .

PHYTOMEDICINE, 2019, 58

← 1 2 3 →