Sensitization to PR-10 proteins is indicative of distinctive sensitization patterns in adults with a suspected food allergy

被引:27
作者
Blankestijn, Mark A. [1 ]
Knulst, Andre C. [1 ]
Knol, Edward F. [1 ,2 ]
Thuy-My Le [1 ]
Rockmann, Heike [1 ]
Otten, Henny G. [2 ]
Klemans, Rob J. B. [1 ]
机构
[1] Univ Utrecht, Univ Med Ctr Utrecht, Dept Dermatol & Allergol, Heidelberglaan 100, NL-3584 CX Utrecht, Netherlands
[2] Univ Utrecht, Univ Med Ctr Utrecht, Lab Translat Immunol, Heidelberglaan 100, NL-3584 CX Utrecht, Netherlands
关键词
ImmunoCAP ISAC; Food allergy; PR-10; Specific IgE; Storage proteins; IGE CROSS-REACTIVITY; LIPID TRANSFER PROTEIN; BIRCH POLLEN ALLERGEN; ARA H 2; IMMUNOGLOBULIN-E; PEANUT ALLERGY; MAJOR ALLERGEN; SEASONAL-VARIATION; HAZELNUT ALLERGY; APPLE;
D O I
10.1186/s13601-017-0177-4
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
Background: The extent of co-sensitization within and between food protein families in an adult population is largely unknown. This study aimed to identify the most frequently recognized components in the PR-10 and storage protein family, as well as patterns in (co-)sensitization, in a birch-endemic area. Methods: Results of ImmunoCAP ISAC, performed during routine care in Dutch adult outpatients suspected of food allergy, were collected. Results: A total of 305 patients were selected, aged 16-79 years (median 32 years). Sensitization to one or more PR-10 proteins was most frequent (74% of all subjects), followed by 35% to storage protein and 15% to nsLTPs. Within the PR-10 family, subjects were most often sensitized to Bet v 1 (73% of 305), Cor a 1.04 (72%) and Mal d 1 (68%). Sensitization to PR-10s from soy, celery and kiwi occurred distinctively less often (< 55% of Bet v 1 sensitized subjects) compared to other food PR-10s (all > 70%). Subjects sensitized to these 'less common PR-10 proteins' were sensitized to more food and inhalant components on the ISAC, compared to subjects sensitized to 'common PR-10 proteins' (median 22 vs 13 out of 112, p < 0.0001). Seven subjects demonstrated sensitization to food PR-10 proteins, without concomitant sensitization to pollen PR-10s. Within the storage proteins, sensitization to multiple peanut allergens was most common (on average 3 out of 4). Conclusions: Sensitization to PR-10 food proteins could occur without concomitant sensitization to common PR-10 from pollen in a subset of subjects. Less commonly recognized PR-10 proteins appear to be an indication of polysensitization.
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页数:8
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