RB regulates the stability and the apoptotic function of p53 via MDM2

被引：226
作者：
Hsieh, JK
Chan, FSG
O'Connor, DJ
Mittnacht, S
Zhong, S
Lu, X
机构：
[1] Imperial Coll Sch Med, Ludwig Inst Canc Res, London W2 1PG, England
[2] Inst Canc Res, London SW3 6JB, England
来源：
MOLECULAR CELL | 1999年 / 3卷 / 02期
关键词：
D O I：
10.1016/S1097-2765(00)80309-3
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The binding of RE to MDM2 is shown to be essential for RE to overcome both the antiapoptotic function of MDM2 and the MDMP-dependent degradation of p53. The RB-MDM2 interaction does not prevent MDM2 from inhibiting p53-dependent transcription, but the RB-MDM2 complex still binds to p53. Since RE specifically rescues the apoptotic function but not the transcriptional activity of p53 from negative regulation by MDM2, transactivation by wild-type p53 is not required for the apoptotic function of p53. However, an RB-MDM2-p53 trimeric complex is active in p53-mediated transrepression. These data link directly the function of two tumor suppressor proteins and demonstrate a novel role of RE in regulating the apoptotic function of p53.
引用
收藏
页码：181 / 193
页数：13
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