Sensitive Voltammetric Determination of Captopril Using a Carbon Paste Electrode Modified with Nano-TiO2/Ferrocene Carboxylic Acid

被引：49

作者：

Raoof, Jahan Bakhsh ^{[1
]}

Ojani, Reza ^{[1
]}

Baghayeri, Mehdi ^{[1
]}

机构：

[1] Mazandaran Univ, Fac Chem, Dept Analyt Chem, Electroanalyt Chem Res Lab, Babol Sar 4741695447, Iran

来源：

CHINESE JOURNAL OF CATALYSIS | 2011年 / 32卷 / 11期

关键词：

electrocatalysis; modified electrode; nano-TiO2; ferrocene carboxylic acid captopril; cyclic voltammetry; SPECTROPHOTOMETRIC DETERMINATION; ELECTROCATALYTIC OXIDATION; SENSOR; FILM; PENICILLAMINE; BEHAVIOR; NANOPARTICLES; DEGRADATION; NANOTUBES; UV;

D O I：

10.1016/S1872-2067(10)60268-9

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A carbon paste electrode (CH) modified with ferrocene carboxylic acid (FcCA) and TiO2 nanoparticles was constructed by incorporating TiO2 nanoparticles and ferrocene carboxylic acid into the carbon paste matrix. The electrochemical behavior of captopril (CAP) at the surface of the modified electrode was investigated using electroanalytical methods. The modified electrode showed excellent electrocatalytic activity for the oxidation of CAP in aqueous solutions at physiological pH values. Cyclic voltammetric curves showed that the oxidation of CAP at the surface of the modified electrode reduced its overpotential by more than 290 mV. The modified electrode was used for detecting captopril using cyclic voltammetry and square wave voltammetry techniques. A calibration curve in the range of 0.03 to 2400 mu mol/L was obtained that had a detection limit of 0.0096 mu mol/L (3 sigma) under the optimized conditions. The modified electrode was successfully used for the determination of captopril in pharmaceutical and biological samples.

引用

页码：1685 / 1692

页数：8

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