Concise Synthesis of Two β-Adrenergic Blocking Agents in High Stereoselectivity Using the Readily Available Chiral Building Block (2S,2′S,2"S)-Tris-(2,3-epoxypropyl)-isocyanurate

被引：6

作者：

Sonawane, Swapnil P. ^{[1
]}

Patil, Gulabrao D. ^{[1
]}

Gurjar, Mukund K. ^{[1
]}

机构：

[1] Emcure Pharmaceut Ltd, API R&D Ctr, MIDC, Pune 411057, Maharashtra, India

来源：

ORGANIC PROCESS RESEARCH & DEVELOPMENT | 2011年 / 15卷 / 06期

关键词：

CHEMOENZYMATIC SYNTHESIS; ASYMMETRIC DIHYDROXYLATION; EFFICIENT SYNTHESIS; PRACTICAL SYNTHESES; KINETIC RESOLUTION; OPTICAL ISOMERS; PROPRANOLOL; (S)-PROPRANOLOL; LIPASE; ROUTE;

D O I：

10.1021/op2001518

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A concise synthesis of (S)-propranolol and (S)-metoprolol in high stereoselectivity using the readily available chiral building block (2S,2'S,2 '' S)-tris-(2,3-epoxypropyl)-isocyanurate (S-TGT) as the key intermediate is described.

引用

页码：1365 / 1370

页数：6

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