Synthetic ligands that activate and inhibit a quorum-sensing regulator in Pseudomonas aeruginosa

被引：61

作者：

Mattmann, Margrith E. ^{[1
]}

Geske, Grant D. ^{[1
]}

Worzalla, Gregory A. ^{[1
,2
]}

Chandler, Josephine R. ^{[3
]}

Sappington, Kaia J. ^{[3
]}

Greenberg, E. Peter ^{[3
]}

Blackwell, Helen E. ^{[1
]}

机构：

[1] Univ Wisconsin, Dept Chem, Madison, WI 53706 USA

[2] Univ Wisconsin, Dept Bacteriol, Madison, WI 53706 USA

[3] Univ Washington, Sch Med, Dept Microbiol, Seattle, WA 98195 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2008年 / 18卷 / 10期

关键词：

D O I：

10.1016/j.bmcl.2007.11.095

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The transcription factor QscR is a regulator of quorum sensing in Pseudomonas aeruginosa and plays a role in controlling virulence in this prevalent opportunistic pathogen. This study outlines the discovery of a set of synthetic N-acylated homoserine lactones that are capable of either activating or strongly inhibiting QscR in a cell-based reporter gene assay. We demonstrate that the synthetic antagonists inhibit ligand-dependent QscR binding to DNA. Several of these ligands can selectively modulate QscR instead of LasR, or modulate the activity of both receptors, and represent new chemical tools to study the hierarchy of quorum-sensing signaling in P. aeruginosa. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：3072 / 3075

页数：4

共 50 条

[31] In silico Screening of Flavones and its Derivatives as Potential Inhibitors of Quorum-Sensing Regulator LasR of Pseudomonas aeruginosa
N. Abelyan
H. Grabski
S. Tiratsuyan
Molecular Biology, 2020, 54 : 134 - 143
[32] QscR, a modulator of quorum-sensing signal synthesis and virulence in Pseudomonas aeruginosa
Chugani, SA
Whiteley, M
Lee, KM
D'Argenio, D
Manoil, C
Greenberg, EP
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (05) : 2752 - 2757
[33] Modeling rhl quorum-sensing regulation on rhamnolipid production by Pseudomonas aeruginosa
Chen, F
Chen, CC
Riadi, L
Ju, LK
BIOTECHNOLOGY PROGRESS, 2004, 20 (05) : 1325 - 1331
[34] Grapefruit essential oils inhibit quorum sensing of Pseudomonas aeruginosa
Luciardi, Maria C.
Amparo Blazquez, M.
Alberto, Maria R.
Cartagena, Elena
Arena, Mario E.
FOOD SCIENCE AND TECHNOLOGY INTERNATIONAL, 2020, 26 (03) : 231 - 241
[35] A quorum-sensing inhibitor blocks Pseudomonas aeruginosa virulence and biofilm formation
O'Loughlin, Colleen T.
Miller, Laura C.
Siryaporn, Albert
Drescher, Knut
Semmelhack, Martin F.
Bassler, Bonnie L.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (44) : 17981 - 17986
[36] Inactivation of a Pseudomonas aeruginosa quorum-sensing signal by human airway epithelia
Chun, CK
Ozer, EA
Welsh, MJ
Zabner, J
Greenberg, EP
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (10) : 3587 - 3590
[37] Strain-dependent diversity in the Pseudomonas aeruginosa quorum-sensing regulon
Chugani, Sudha
Kim, Byoung Sik
Phattarasukol, Somsak
Brittnacher, Mitchell. J.
Choi, Sang Ho
Harwood, Caroline S.
Greenberg, E. Peter
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (41) : E2823 - E2831
[38] Pseudomonas aeruginosa pyocyanin production reduced by quorum-sensing inhibiting nanocarriers
Lu, Hoang D.
Pearson, Elizabeth
Ristroph, Kurt D.
Duncan, Gregg A.
Ensign, Laura M.
Suk, Jung Soo
Hanes, Justin
Prud'homme, Robert K.
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2018, 544 (01) : 75 - 82
[39] Correction: Corrigendum: Mechanistic analysis of a synthetic inhibitor of the Pseudomonas aeruginosa LasI quorum-sensing signal synthase
O. Lidor
A. Al-Quntar
E. C. Pesci
D. Steinberg
Scientific Reports, 6
[40] Quorum-sensing regulation of the biofilm matrix genes (pel) of Pseudomonas aeruginosa
Sakuragi, Yumiko
Kolter, Roberto
JOURNAL OF BACTERIOLOGY, 2007, 189 (14) : 5383 - 5386

← 1 2 3 4 5 →