Isolation and Structural Elucidation of Proline-Containing Cyclopentapeptides from an Endolichenic Xylaria sp.

被引：76

作者：

Wu, Wen ^{[1
,2
]}

Dai, Huanqin ^{[2
]}

Bao, Li ^{[2
]}

Ren, Biao ^{[2
]}

Lu, Jingcai ^{[1
]}

Luo, Yuanming ^{[2
]}

Guo, Liangdong ^{[2
]}

Zhang, Lixin ^{[2
]}

Liu, Hongwei ^{[2
]}

机构：

[1] Shenyang Pharmaceut Univ, Coll Tradit Chinese Mat Med, Shenyang 110016, Peoples R China

[2] Chinese Acad Sci, Inst Microbiol, Key Lab Systemat Mycol & Lichenol, Beijing 100190, Peoples R China

来源：

JOURNAL OF NATURAL PRODUCTS | 2011年 / 74卷 / 05期

关键词：

ACID-DERIVATIVES; METABOLITES; AGENTS;

D O I：

10.1021/np100909y

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two new cyclic pentapeptides (1 and 2) and the known blazein (3), ganodesterone (4), ergosterin (5), cerevisterol (6), 24-methylcholesta-4,6,8(14),22-tetraen-3-one (7), 5,8-epidioxyergosta-6,22-dien-3-ol (8), 16-alpha-D-mannopyranosyloxyisopimar-7-en-19-oic acid (9), and 16-hydroxy isopimar-7-en-19-oic acid (10) have been isolated from the crude extract of an endolichenic Xylaria sp. The structures of 1 and 2 were elucidated primarily by NMR and MS methods. The absolute configurations of 1 and 2 were assigned using Marfey's method on their acid hydrolysate. Compounds 1-10 were evaluated for activity against fungi and for synergistic antifungal activity. Compound 1 showed synergistic antifungal activity against Candida albicans SC5314 with 0.004 mu g/mL ketoconazole.

引用

页码：1303 / 1308

页数：6

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