Natural products as leads to potential drugs: An old process or the new hope for drug discovery?

被引：517
|
作者：
Newman, David J. [1 ]
机构：
[1] NCI Frederick, Dev Therapeut Program, Nat Prod Branch, Frederick, MD 21702 USA
来源：
JOURNAL OF MEDICINAL CHEMISTRY | 2008年 / 51卷 / 09期
关键词：
D O I：
10.1021/jm0704090
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
[No abstract available]
引用
收藏
页码：2589 / 2599
页数：11
相关论文
共 50 条
  • [21] Teaching an old dog new tricks: Drug discovery by repositioning natural products and their derivatives
    Huang, Boshi
    Zhang, Yan
    DRUG DISCOVERY TODAY, 2022, 27 (07) : 1936 - 1944
  • [22] Natural products discovery and potential for new antibiotics
    Genilloud, Olga
    CURRENT OPINION IN MICROBIOLOGY, 2019, 51 : 81 - 87
  • [23] Natural Products Towards the Discovery of Potential Future Antithrombotic Drugs
    Islam, Md. Asiful
    Alam, Fahmida
    Khalil, Md. Ibrahim
    Sasongko, Teguh Haryo
    Gan, Siew Hua
    CURRENT PHARMACEUTICAL DESIGN, 2016, 22 (20) : 2926 - 2946
  • [24] Natural Products as Leads for Anticancer Drug Discovery: Discovery of New Chemotypes of Microtubule Stabilizers through Reengineering of the Epothilone Scaffold
    Altmann, Karl-Heinz
    Cachoux, Frederic
    Feyen, Fabian
    Gertsch, Juerg
    Kuzniewski, Christian N.
    Wartmann, Markus
    CHIMIA, 2010, 64 (1-2) : 8 - 13
  • [25] Discovery of plant-derived anti-tumor natural products: Potential leads for anti-tumor drug discovery
    Hui, Zi
    Wen, Hao
    Zhu, Junlong
    Deng, Haowen
    Jiang, Xiaoying
    Ye, Xiang-Yang
    Wang, Liwei
    Xie, Tian
    Bai, Renren
    BIOORGANIC CHEMISTRY, 2024, 142
  • [26] Natural products as leads to anticancer drugs
    Gordaliza, M.
    CLINICAL & TRANSLATIONAL ONCOLOGY, 2007, 9 (12): : 767 - 776
  • [27] Natural products as leads to antitumor drugs
    Newman, David J.
    Giddings, Lesley-Ann
    PHYTOCHEMISTRY REVIEWS, 2014, 13 (01) : 123 - 137
  • [28] Natural products as leads to anticancer drugs
    M. Gordaliza
    Clinical and Translational Oncology, 2007, 9 : 767 - 776
  • [29] Natural products as leads to antitumor drugs
    David J. Newman
    Lesley-Ann Giddings
    Phytochemistry Reviews, 2014, 13 : 123 - 137
  • [30] Natural products as sources of and leads to drugs
    Newman, David J.
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2011, 241
12345