Multisite EPR oximetry from multiple quadrature harmonics

被引：4

作者：

Ahmad, R. ^{[1
]}

Som, S. ^{[2
]}

Johnson, D. H. ^{[1
]}

Zweier, J. L. ^{[1
]}

Kuppusamy, P. ^{[1
]}

Potter, L. C. ^{[3
]}

机构：

[1] Ohio State Univ, Dept Internal Med, Davis Heart & Lung Res Inst, Columbus, OH 43210 USA

[2] Georgia Inst Technol, Sch Elect & Comp Engn, Atlanta, GA 30308 USA

[3] Ohio State Univ, Dept Elect & Comp Engn, Columbus, OH 43210 USA

来源：

JOURNAL OF MAGNETIC RESONANCE | 2012年 / 214卷

关键词：

EPR; Digital detection; Overmodulation; Quadrature harmonics; Multisite; Oximetry; IN-VIVO EPR; LINEWIDTH; SIGNAL; RECONSTRUCTION; SPECTROMETER; MODULATION; HYPEROXIA; SPECTRUM; HYPOXIA; TISSUES;

D O I：

10.1016/j.jmr.2011.10.016

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Multisite continuous wave (CW) electron paramagnetic resonance (EPR) oximetry using multiple quadrature field modulation harmonics is presented. First, a recently developed digital receiver is used to extract multiple harmonics of field modulated projection data. Second, a forward model is presented that relates the projection data to unknown parameters, including linewidth at each site. Third, a maximum likelihood estimator of unknown parameters is reported using an iterative algorithm capable of jointly processing multiple quadrature harmonics. The data modeling and processing are applicable for parametric lineshapes under nonsaturating conditions. Joint processing of multiple harmonics leads to 2-3-fold acceleration of EPR data acquisition. For demonstration in two spatial dimensions, both simulations and phantom studies on an L-band system are reported. (C) 2011 Elsevier Inc. All rights reserved.

引用

页码：135 / 143

页数：9

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