Topical 5-aminolaevulinic acid photodynamic therapy for extensive scalp actinic keratoses

被引:24
作者
Markham, T [1 ]
Collins, P [1 ]
机构
[1] City Dublin Skin & Canc Hosp, Dublin 2, Ireland
关键词
actinic keratoses; scalp; topical 5-aminolaevulinic acid photodynamic therapy;
D O I
10.1046/j.1365-2133.2001.04385.x
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Scalp actinic keratoses (AKs) are common, particularly in elderly bald males. Cryotherapy and 5-fluorouracil are effective for localized AKs but are limited in extensive disease. Topical 5-aminolaevulinic acid photodynamic therapy (5-ALA PDT) is an alternative. We treated four patients with extensive scalp AKs with low light dose, low dose-rate topical 5-ALA PDT using a broad-spectrum visible light source. Three patients cleared and one showed significant improvement. Remission lasted 6 months.
引用
收藏
页码:502 / 504
页数:3
相关论文
共 13 条
[1]  
GOMER CJ, 1983, CANCER RES, V43, P2622
[2]   Photodynamic therapy of actinic keratosis with topical 5-aminolevulinic acid - A pilot dose-ranging study [J].
Jeffes, EW ;
McCullough, JL ;
Weinstein, GD ;
Fergin, PE ;
Nelson, JS ;
Shull, TF ;
Simpson, KR ;
Bukaty, LM ;
Hoffman, WL ;
Fong, NL .
ARCHIVES OF DERMATOLOGY, 1997, 133 (06) :727-732
[3]   PHOTODYNAMIC THERAPY WITH ENDOGENOUS PROTOPORPHYRIN .9. BASIC PRINCIPLES AND PRESENT CLINICAL-EXPERIENCE [J].
KENNEDY, JC ;
POTTIER, RH ;
PROSS, DC .
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, 1990, 6 (1-2) :143-148
[4]   A randomized paired comparison of photodynamic therapy and. topical 5-fluorouracil in the treatment of actinic keratoses [J].
Kurwa, HA ;
Yong-Gee, SA ;
Seed, PT ;
Markey, AC ;
Barlow, RJ .
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 1999, 41 (03) :414-418
[5]  
MOAN J, 1980, CANCER RES, V40, P2915
[6]   Comparison of photodynamic therapy with cryotherapy in the treatment of Bowen's disease [J].
Morton, CA ;
Whitehurst, C ;
Moseley, H ;
Mccoll, JH ;
Moore, JV ;
Mackie, RM .
BRITISH JOURNAL OF DERMATOLOGY, 1996, 135 (05) :766-771
[7]   5-aminolevulinic acid-based photodynamic therapy: Principles and experimental research [J].
Peng, Q ;
Berg, K ;
Moan, J ;
Kongshaug, M ;
Nesland, JM .
PHOTOCHEMISTRY AND PHOTOBIOLOGY, 1997, 65 (02) :235-251
[8]   Fluorescence photobleaching of ALA-induced protoporphyrin IX during photodynamic therapy of normal hairless mouse skin: The effect of light dose and irradiance and the resulting biological effect [J].
Robinson, DJ ;
de Bruijn, HS ;
van der Veen, N ;
Stringer, MR ;
Brown, SB ;
Star, WM .
PHOTOCHEMISTRY AND PHOTOBIOLOGY, 1998, 67 (01) :140-149
[9]  
Salasche S J, 2000, J Am Acad Dermatol, V42, P4
[10]   The accumulation of protoporphyrin IX in plaque psoriasis after topical application of 5-aminolevulinic acid indicates a potential for superficial photodynamic therapy [J].
Stringer, MR ;
Collins, P ;
Robinson, DJ ;
Stables, GI ;
SheehanDare, RA .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1996, 107 (01) :76-81