Silver(I) and copper(I) complexes with a Schiff base derived from 2-aminofluorene with promising antibacterial activity

被引：16

作者：

Cifuentes-Vaca, Olga L. ^{[1
,2
]}

Andrades-Lagos, Juan ^{[3
]}

Campanini-Salinas, Javier ^{[4
]}

Laguna, Antonio ^{[1
]}

Vasquez-Velasquez, David ^{[3
]}

Concepcion Gimeno, M. ^{[1
]}

机构：

[1] Univ Zaragoza, Dept Quim Inorg, CSIC, ISQCH, E-50009 Zaragoza, Spain

[2] Univ Andres Bello, Fac Ciencias Exactas, Dept Ciencias Quim, Sede Concepcion, Autopista Concepcion Talcahuano, Talcahuano 7100, Chile

[3] Univ Chile, Fac Ciencias Quim & Farmaceut, Dept Quim Farmacol & Toxizol, Sergio Livingstone 1007, Santiago 8380492, Chile

[4] Univ San Sebastian, Fac Med & Ciencia, Lago Panguipulli 1390, Puerto Montt 550182, Chile

来源：

INORGANICA CHIMICA ACTA | 2019年 / 489卷

关键词：

CO(II) COMPLEXES; CU(II); NI(II); DNA; BINDING; LIGANDS; DFT;

D O I：

10.1016/j.ica.2019.02.033

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

By reaction of 2-aminofluorene with 2-pyridinecarboxaldehyde a new Schiff base (L) is obtained. The reaction of this ligand with Ag(I) and Cu(I) salts in different stoichiometry leads to the complexes [Ag(CF3SO3 )(L)PPh3] (1) or [ML2]A (M = Ag, Cu; A = CF3SO3, ClO4 or BF4). Structural characterization by X-ray crystallography has been carried out for complexes [AgL2]ClO4 (4) and [Ag(L)(PPh3)(2)] (CF3SO3) (6), which confirms the chelate nature of L and the presence of Ag center dot center dot center dot H interactions between two molecules. The biological studies show that Schiff base L presents antibacterial activity in Gram-positive bacteria and E. coli. The coordination to silver increases this activity, but the formation of the copper complex does not generate significant changes.

引用

页码：275 / 279

页数：5

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