Brief Report: A Gene Enrichment Approach Applied to Sleep and Autism

被引：7

作者：

Abel, Emily A. ^{[1
,2
]}

Schwichtenberg, A. J. ^{[1
]}

Mannin, Olivia R. ^{[1
]}

Marceau, Kristine ^{[1
]}

机构：

[1] Purdue Univ, Dept Human Dev & Family Studies, 1202 West State St, W Lafayette, IN 47907 USA

[2] Yale Univ, Yale Child Study Ctr, New Haven, CT 06520 USA

来源：

JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS | 2020年 / 50卷 / 05期

关键词：

Sleep; Gene; Syndrome; Autism spectrum disorder; Circadian; Melatonin; HIGH-FUNCTIONING AUTISM; SPECTRUM DISORDER; CHILDREN; MELATONIN; CA(V)1.2; ADULTS; RHYTHM; CLOCK;

D O I：

10.1007/s10803-019-03921-5

中图分类号：

B844 [发展心理学（人类心理学）];

学科分类号：

040202 ;

摘要：

Sleep disorders (SD) are common in autism spectrum disorder (ASD), yet relatively little is known about the potential genetic mechanisms involved in SD and ASD comorbidity. The current study begins to fill this gap with a gene enrichment study that (1) identifies risk genes that contribute to both SD and ASD which implicate circadian entrainment, melatonin synthesis, and several genetic syndromes. An over-representation analysis identified several enriched pathways that suggest dopamine and serotonin synapses as potential shared SD and ASD mechanisms. This overlapping gene set and the highlighted biological pathways may serve as a preliminary stepping-stone for new genetic investigations of SD and ASD comorbidity.

引用

页码：1834 / 1840

页数：7

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