Discovery of the First Neurotransmitter Receptor: The Acetylcholine Nicotinic Receptor

被引：31

作者：

Changeux, Jean-Pierre ^{[1
,2
]}

机构：

[1] Inst Pasteur, CNRS, Dept Neurosci, UMR 3571, F-75015 Paris, France

[2] Coll France, F-75015 Paris, France

来源：

BIOMOLECULES | 2020年 / 10卷 / 04期

基金：

欧盟地平线“2020”;

关键词：

pharmacological receptor; nicotinic acetylcholine receptor; first identification of a receptor; history of neuroscience; ANTIBODY ACTIVE-SITES; GATED ION-CHANNEL; TORPEDO-MARMORATA; ALPHA-SUBUNIT; ELECTROPHORUS-ELECTRICUS; QUATERNARY STRUCTURE; MOLECULAR-CLONING; PROTEIN; PURIFICATION; SEQUENCE;

D O I：

10.3390/biom10040547

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The concept of pharmacological receptor was proposed at the turn of the 20th century but it took almost 70 years before the first receptor for a neurotransmitter was isolated and identified as a protein. This review retraces the history of the difficulties and successes in the identification of the nicotinic acetylcholine receptor, the first neurotransmitter receptor to be identified.

引用

页数：15

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