Discovery of the First Neurotransmitter Receptor: The Acetylcholine Nicotinic Receptor

被引：31

作者：

Changeux, Jean-Pierre ^{[1
,2
]}

机构：

[1] Inst Pasteur, CNRS, Dept Neurosci, UMR 3571, F-75015 Paris, France

[2] Coll France, F-75015 Paris, France

来源：

BIOMOLECULES | 2020年 / 10卷 / 04期

基金：

欧盟地平线“2020”;

关键词：

pharmacological receptor; nicotinic acetylcholine receptor; first identification of a receptor; history of neuroscience; ANTIBODY ACTIVE-SITES; GATED ION-CHANNEL; TORPEDO-MARMORATA; ALPHA-SUBUNIT; ELECTROPHORUS-ELECTRICUS; QUATERNARY STRUCTURE; MOLECULAR-CLONING; PROTEIN; PURIFICATION; SEQUENCE;

D O I：

10.3390/biom10040547

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The concept of pharmacological receptor was proposed at the turn of the 20th century but it took almost 70 years before the first receptor for a neurotransmitter was isolated and identified as a protein. This review retraces the history of the difficulties and successes in the identification of the nicotinic acetylcholine receptor, the first neurotransmitter receptor to be identified.

引用

页数：15

共 50 条

[1] The nicotinic acetylcholine receptor: a typical 'allosteric machine'
Changeux, Jean-Pierre
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 2018, 373 (1749)
[2] Recent Advances in the Discovery of Nicotinic Acetylcholine Receptor Allosteric Modulators
Manetti, Dina
Dei, Silvia
Arias, Hugo R.
Braconi, Laura
Gabellini, Alessio
Teodori, Elisabetta
Romanelli, Maria Novella
MOLECULES, 2023, 28 (03):
[3] Discovery of a novel series of quinolone α7 nicotinic acetylcholine receptor agonists
McDonald, Ivar M.
Mate, Robert A.
Zusi, F. Christopher
Huang, Hong
Post-Munson, Debra J.
Ferrante, Meredith A.
Gallagher, Lizbeth
Bertekap, Robert L., Jr.
Knox, Ronald J.
Robertson, Barbara J.
Harden, David G.
Morgan, Daniel G.
Lodge, Nicholas J.
Dworetzky, Steven I.
Olson, Richard E.
Macor, John E.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2013, 23 (06) : 1684 - 1688
[4] Probing the structure of the uncoupled nicotinic acetylcholine receptor
Sun, Jiayin
Comeau, J. Frederique
Baenziger, John E.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 2017, 1859 (02): : 146 - 154
[5] Boundary Lipids In The Nicotinic Acetylcholine Receptor Microenvironment
Barrantes, Francisco J.
Bermudez, V.
Borroni, M. V.
Antollini, S. S.
Pediconi, M. F.
Baier, J. C.
Bonini, I.
Gallegos, C.
Roccamo, A. M.
Valles, A. S.
Ayala, V.
Kamerbeek, C.
JOURNAL OF MOLECULAR NEUROSCIENCE, 2010, 40 (1-2) : 87 - 90
[6] Diversity of Insect Nicotinic Acetylcholine Receptor Subunits
Jones, Andrew K.
Sattelle, David B.
INSECT NICOTINIC ACETYLCHOLINE RECEPTORS, 2010, 683 : 25 - 43
[7] Nanoscale interactions between the nicotinic acetylcholine receptor and cholesterol
Barrantes, Francisco J.
BIOCELL, 2021, 45 (06) : 1479 - 1484
[8] DISCOVERY OF A POTENT AND SELECTIVE NICOTINIC ACETYLCHOLINE RECEPTOR ANTAGONIST FROM A CONOTOXIN COMBINATORIAL LIBRARY
Chang, Y-P.
Banerjee, J.
Dowell, C.
Wu, J.
Gyanda, R.
Houghten, R. A.
Toll, L.
McIntosh, J. M.
Armishaw, C. J.
JOURNAL OF PEPTIDE SCIENCE, 2014, 20 : S238 - S239
[9] Nicotinic acetylcholine receptor is involved in acetylcholine regulating stomatal movement
王恒彬
王学臣
张蜀秋
娄成后
Science in China(Series C:Life Sciences), 1998, (06) : 650 - 656
[10] Nicotinic acetylcholine receptor is involved in acetylcholine regulating stomatal movement
Hengbin Wang
Xuechen Wang
Shuqiu Zhang
Chenghou Lou
Science in China Series C: Life Sciences, 1998, 41 : 650 - 656

← 1 2 3 4 5 →