Human T-cell leukemia virus type-I (HTLV-I) tax is not the only one factor to enhance human immunodeficiency virus type-1 (HIV-1) infection in culture-supernatants

被引：0

作者：

Tempaku, A ^{[1
]}

Maeda, Y ^{[1
]}

Song, W ^{[1
]}

Harada, S ^{[1
]}

机构：

[1] Kumamoto Univ, Sch Med, Dept Biodef & Med Virol, Kumamoto 8600811, Japan

来源：

VIRUS GENES | 2001年 / 23卷 / 01期

关键词：

HIV-1; enhancing factors; HTLV-I; Tax; pseudotyped virus;

D O I：

10.1023/A:1011139530768

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

It is hypothesized that supernatants from cell cultures contain several factors to modify the human immunodeficiency virus type-1 (HIV-1) infection. Single round infection with pseudotyped viruses with envelope from HIV-1, amphotropic murine leukemia virus (A-MLV) and vesicular stomatitis virus G-protein (VSV-G) carrying luciferase reporter gene detected that not only human T-cell leukemia/lymphoma virus type-I (HTLV-I) transformed cells but also HTLV-I-unrelated T-cells and BJA-B cells released factors enhancing the infection with all pseudotyped viruses in their culture-supernatants. No supernatants upregulated the level of transcription from transfected DNA probe, suggesting that the action of supernatants is different from that of tumor necrosis factor (TNF) and Tax of HTLV-I. These results indicated that factors not always related to HTLV-I were ubiquitously produced and promoted viral infections, probably due to non-specific enhancement of early phase of the infection.

引用

页码：77 / 80

页数：4

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