Mast cells in atherosclerosis

被引：56
作者：
Bot, Ilze [1 ]
Biessen, Erik A. L. [2 ]
机构：
[1] Leiden Univ, Gorlaeus Labs, Div Biopharmaceut, Leiden Amsterdam Ctr Drug Res, NL-2333 CC Leiden, Netherlands
[2] Univ Maastricht, Maastricht, Netherlands
来源：
THROMBOSIS AND HAEMOSTASIS | 2011年 / 106卷 / 05期
关键词：
Atherosclerosis; mast cell; plaque stability; proteases; cytokines; acute cardiovascular syndromes; LOW-DENSITY-LIPOPROTEIN; ACUTE CORONARY SYNDROMES; MYOCARDIAL-INFARCTION; PROMOTE ATHEROSCLEROSIS; COMPLEMENT ACTIVATION; ENDOTHELIAL-CELLS; APOLIPOPROTEIN-B; SHOULDER REGION; TRYPTASE LEVELS; ARTERY-DISEASE;
D O I：
10.1160/TH11-05-0291
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The mast cell, a potent inflammatory cell type, is widely distributed over several tissues, but particularly prominent at the interface exposed to the environment to act in the first line of defense against pathogens. Upon activation mast cells release granules, which contain a large panel of mediators, including neutral proteases (e.g. chymase and tryptase), cathepsins, heparin, histamine and a variety of cytokines and growth factors. While mast cells have been demonstrated to be critically involved in a number of Th2 dominated diseases such as asthma and allergy, recent investigations have now also implicated mast cells in the pathogenesis of atherosclerosis and acute cardiovascular syndromes. In this review, we will discuss the contribution of mast cells to the initiation and progression of atherosclerosis and gauge the therapeutic opportunities of mast cell targeted intervention in acute cardiovascular syndromes.
引用
收藏
页码：820 / 826
页数：7
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