Is Serum Methylmalonic Acid a Reliable Biomarker of Vitamin B12 Status in Children with Short Bowel Syndrome: A Case Series

被引：16

作者：

Jimenez, Lissette ^{[1
,2
]}

Stamm, Danielle A. ^{[2
,3
]}

Depaula, Brittany ^{[1
,2
]}

Duggan, Christopher P. ^{[1
,2
]}

机构：

[1] Harvard Med Sch, Boston Childrens Hosp, Div Gastroenterol Hepatol & Nutr, Boston, MA USA

[2] Harvard Med Sch, Boston Childrens Hosp, Ctr Adv Intestinal Rehabil, Boston, MA USA

[3] Harvard Med Sch, Boston Childrens Hosp, Dept Surg, Boston, MA USA

来源：

JOURNAL OF PEDIATRICS | 2018年 / 192卷

基金：

美国国家卫生研究院;

关键词：

MULTIPLE MICRONUTRIENT DEFICIENCIES; INTESTINAL BACTERIAL OVERGROWTH; FAILURE; MANAGEMENT; COBALAMIN;

D O I：

10.1016/j.jpeds.2017.09.024

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

We describe 3 patients with short bowel syndrome who had persistently elevated serum methylmalonic acid (MMA) levels while being treated for vitamin B12 deficiency. Following treatment for presumed small bowel bacterial over-growth, MMA levels normalized. Among patients with short bowel syndrome, MMA levels may have limited specificity for vitamin B12 deficiency.

引用

页码：259 / 261

页数：3

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