Is Serum Methylmalonic Acid a Reliable Biomarker of Vitamin B12 Status in Children with Short Bowel Syndrome: A Case Series

被引：16
作者：
Jimenez, Lissette [1 ,2 ]
Stamm, Danielle A. [2 ,3 ]
Depaula, Brittany [1 ,2 ]
Duggan, Christopher P. [1 ,2 ]
机构：
[1] Harvard Med Sch, Boston Childrens Hosp, Div Gastroenterol Hepatol & Nutr, Boston, MA USA
[2] Harvard Med Sch, Boston Childrens Hosp, Ctr Adv Intestinal Rehabil, Boston, MA USA
[3] Harvard Med Sch, Boston Childrens Hosp, Dept Surg, Boston, MA USA
来源：
JOURNAL OF PEDIATRICS | 2018年 / 192卷
基金：
美国国家卫生研究院;
关键词：
MULTIPLE MICRONUTRIENT DEFICIENCIES; INTESTINAL BACTERIAL OVERGROWTH; FAILURE; MANAGEMENT; COBALAMIN;
D O I：
10.1016/j.jpeds.2017.09.024
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
We describe 3 patients with short bowel syndrome who had persistently elevated serum methylmalonic acid (MMA) levels while being treated for vitamin B12 deficiency. Following treatment for presumed small bowel bacterial over-growth, MMA levels normalized. Among patients with short bowel syndrome, MMA levels may have limited specificity for vitamin B12 deficiency.
引用
收藏
页码：259 / 261
页数：3
相关论文
共 22 条
  • [1] Small intestinal bacterial overgrowth syndrome
    Bures, Jan
    Cyrany, Jiri
    Kohoutova, Darina
    Foerstl, Miroslav
    Rejchrt, Stanislav
    Kvetina, Jaroslav
    Vorisek, Viktor
    Kopacova, Marcela
    [J]. WORLD JOURNAL OF GASTROENTEROLOGY, 2010, 16 (24) : 2978 - 2990
  • [2] INTRAJEJUNAL VOLATILE FATTY-ACIDS IN STAGNANT LOOP SYNDROME
    CHERNOV, AJ
    GOMPERTZ, D
    DOE, WF
    [J]. GUT, 1972, 13 (02) : 103 - +
  • [3] The Rate of Bloodstream Infection Is High in Infants with Short Bowel Syndrome: Relationship with Small Bowel Bacterial Overgrowth, Enteral Feeding, and Inflammatory and Immune Responses
    Cole, Conrad R.
    Frem, Juliana C.
    Schmotzer, Brian
    Gewirtz, Andrew T.
    Meddings, Jonathan B.
    Gold, Benjamin D.
    Ziegler, Thomas R.
    [J]. JOURNAL OF PEDIATRICS, 2010, 156 (06) : 941 - U117
  • [4] Enteric microbial flora, bacterial overgrowth, and short-bowel syndrome
    DiBaise, JK
    Young, RJ
    Vanderhoof, JA
    [J]. CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 2006, 4 (01) : 11 - 20
  • [5] Dukowicz Andrew C, 2007, Gastroenterol Hepatol (N Y), V3, P112
  • [6] Multiple micronutrient deficiencies in a child with short bowel syndrome and normal somatic growth
    Duro, Debora
    Jaksic, Ttorn
    Duggan, Christopher
    [J]. JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, 2008, 46 (04) : 461 - 464
  • [7] GIANNELLA RA, 1972, GASTROENTEROLOGY, V62, P255
  • [8] Risk factors for small bowel bacterial overgrowth and diagnostic yield of duodenal aspirates in children with intestinal failure: a retrospective review
    Gutierrez, Ivan M.
    Kang, Kuang Horng
    Calvert, Catherine E.
    Johnson, Victor M.
    Zurakowski, David
    Kamin, Daniel
    Jaksic, Tom
    Duggan, Christopher
    [J]. JOURNAL OF PEDIATRIC SURGERY, 2012, 47 (06) : 1150 - 1154
  • [9] Gut microbial diversity is reduced and is associated with colonic inflammation in a piglet model of short bowel syndrome
    Lapthorne, Susan
    Pereira-Fantini, Prue M.
    Fouhy, Fiona
    Wilson, Guineva
    Thomas, Sarah L.
    Dellios, Nicole L.
    Scurr, Michelle
    O'Sullivan, Orla
    Ross, R. Paul
    Stanton, Catherine
    Fitzgerald, Gerald F.
    Cotter, Paul D.
    Bines, Julie E.
    [J]. GUT MICROBES, 2013, 4 (03) : 212 - 221
  • [10] Intestinal dysbiosis in children with short bowel syndrome is associated with impaired outcome
    Lilja, Helene Engstrand
    Wefer, Hugo
    Nystrom, Niklas
    Finkel, Yigael
    Engstrand, Lars
    [J]. MICROBIOME, 2015, 3
123