Flow Cytometry Confirmation Post Newborn Screening for SCID in England

被引：1

作者：

Gilmour, Kimberly C. ^{[1
]}

机构：

[1] Hosp Children NHS Fdn Trust, Camelia Botnar Labs, Immunol Lab, Great Ormond St, London WC1N 3JH, England

来源：

INTERNATIONAL JOURNAL OF NEONATAL SCREENING | 2022年 / 8卷 / 01期

关键词：

severe combined immunodeficiency; TREC; flow cytometry; T cells; SEVERE COMBINED IMMUNODEFICIENCY;

D O I：

10.3390/ijns8010001

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

An evaluation program for newborn screening for Severe Combined Immunodeficiency began in England in September 2021 based on TREC analysis. Flow cytometry is being used as the follow up diagnostic test for patients with low/absent TRECS. The immunology laboratories have established a protocol and values for diagnosing SCID, other T lymphopenias and identifying healthy babies. This commentary describes the flow cytometry approach used in England to define SCID, T lymphopenia and normal infants after a low TREC result. It provides background to the flow cytometry assays being used and discusses the need to monitor and potentially change these values over time.

引用

页数：6

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