pH-Sensitive nanoparticles containing 5-fluorouracil and leucovorin as an improved anti-cancer option for colon cancer

被引：29
作者：
Ibrahim, Bakry [1 ]
Mady, Omar Y. [1 ]
Tambuwala, Murtaza M. [2 ]
Haggag, Yusuf A. [1 ]
机构：
[1] Tanta Univ, Fac Pharm, Dept Pharmaceut Technol, Tanta 31512, Egypt
[2] Ulster Univ, Sch Pharm & Pharmaceut Sci, Coleraine BT52 1SA, Londonderry, North Ireland
来源：
NANOMEDICINE | 2022年 / 17卷 / 06期
关键词：
5-fluorouracil; colon targeting; eudragit S100; large bowel carcinoma; leucovorin; nanoparticles; oral delivery; PARTICLE-SIZE; CHITOSAN NANOPARTICLES; PLGA NANOPARTICLES; DELIVERY-SYSTEMS; MOUSE MODELS; DESIGN; MICROPARTICLES; MICROSPHERES; RELEASE; MICROENCAPSULATION;
D O I：
10.2217/nnm-2021-0423
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Background: Parenteral administration of chemotherapeutic drugs, 5-fluorouracil (5-FU) and leucovorin (LV), is commonly used to treat large bowel carcinomas such as colon cancer (CC) and colorectal carcinoma (CRC). Aim: Our study aims to design a novel nanoparticulate drug-delivery vehicle for oral use capable of colon-specific release. Methods: A modified double-emulsion solvent evaporation method was used in the preparation of pH-responsive Eudargit(R) S100 polymeric nanoparticles, loaded with 5-FU/LV combination (5-FU/LV-loaded Eudargit S100 NPs). Results: Our optimized drug-loaded NP showed a pH-responsive drug release and exhibited significantly more cytotoxic actions in cancer-cell lines than free drugs. Conclusion: These findings open the way for conducting clinical trials for colon malignancies treated with nanoparticles.
引用
收藏
页码：367 / 381
页数：15
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