Introduction: Quality of life (QoL) has been widely studied in the health area and chronic health conditions such as chronic kidney disease (CKD) can interfere with functional capacity, independence and, consequently, QoL, by negative implication In the activities of daily living, emotional, social and cultural issues. Objective: To characterize patients with CKD in hemodialysis (HD) treatment of a clinic in the west of Santa Catarina, their relationships and sociodemographic variables, and their QoL. Methodology: Descriptive cross-sectional study with 116 patients with CKD in HD. To collect data on the questionnaire sociodemographic and a intrument Medical Outcomes Study 36-Item Short-Form Health Survey (SF-36) were used. Results: There was a prevalence of the population aged> 60 years old, Caucasian (74.77%), male (54.31%), of professions related to middle and low class and reduced number of years of study. In relation to comorbidities, Systemic Arterial Hypertension prevailed (38.79%). Regarding QoL, limitations due to physical aspects had lower averages (29.09) and limitations in social activities (73.71). Conclusion: Negative QoL have personal, familial, and social repercussions due to the impact of the disease on the routine life activities of kidney patients.