BsmI (rs1544410) and FokI (rs2228570) vitamin D receptor polymorphisms, smoking, and body mass index as risk factors of cutaneous malignant melanoma in northeast Italy

被引:21
作者
Cauci, Sabina [1 ]
Maione, Vincenzo [2 ]
Buligan, Cinzia [1 ,3 ]
Linussio, Martina [1 ]
Serraino, Diego [4 ]
Stinco, Giuseppe [1 ,3 ]
机构
[1] Univ Udine, Dept Med, I-33100 Udine, Italy
[2] Univ Hosp Brescia, Dermatol Clin, I-25123 Brescia, Italy
[3] Univ Hosp Udine, Dermatol Clin, I-33100 Udine, Italy
[4] CRO Aviano Natl Canc Inst, Unit Canc Epidemiol, I-33081 Aviano, Italy
关键词
1,25-DIHYDROXYVITAMIN D-3; SKIN-CANCER; GENE POLYMORPHISMS; CELL LINES; VDR; METAANALYSIS; COHORT; ASSOCIATION; POPULATION; VARIANTS;
D O I
10.20892/j.issn.2095-3941.2017.0064
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Objective: To investigate whether vitamin D receptor gene (VDR) BsmI-rs1544410 and FokI-rs2228570 polymorphisms, smoking duration, and body mass index (BMI) are risk factors for cutaneous melanoma, especially metastatic melanoma. Methods: We studied 120 cutaneous melanoma cases [68 stage I and II non-metastatic melanoma (NMetM) patients, plus 52 Stage III and IV metastatic melanoma (MetM) patients], and 120 matching healthy controls from northeast Italy. VDR polymorphisms were measured by restriction fragment length polymorphism analysis. Absence or presence of BsmI and FokI restriction sites was denoted by "B" and "F" or by "b" and "f," respectively. Results: VDR-BsmI bb genotype was more frequent among MetM (32.7%) than among NMetM cases (13.2%), with odds ratio (OR)=3.18. Comparison of all melanoma patients vs healthy controls showed that the following biomarkers were at risk: >= 20 years of smoking (OR=2.43); >= 20 years of smoking combined with bb (OR=4.78), Bb+ bb (OR=2.30), Ff (OR=3.04), and Ff+ff (OR=3.08); obesity (BMI>30 kg/m(2)) alone (OR=3.54); and obesity combined with Bb+ bb (OR=3.52), Ff (OR=4.78), and Ff+ff (OR=6.56). Comparison of MetM vs NMetM patients revealed that the following biomarkers were at risk: >= 20 years of smoking (OR=2.39), >= 20 years of smoking combined with bb (OR=5.13), Bb+bb (OR=3.07), and Ff+ff (OR=2.66); and obesity combined with Bb+ bb (OR=5.27), Ff (OR=6.28), and Ff+ff (OR=9.18). Triple combination of >= 20 years of smoking, obesity, and Bb+ bb yielded OR=9.65 for melanoma patients vs healthy controls and OR=12.2 for MetM vs. NMetM patients. Conclusions: Risk factors for cutaneous MetM include two VDR polymorphisms combined with smoking duration and obesity. Results suggest gene-environment implications in melanoma susceptibility and severity. Future studies in larger cohorts and in subjects with different genetic background are warranted to extend our findings.
引用
收藏
页码:302 / 318
页数:17
相关论文
共 61 条
  • [51] Smoking and risk of skin cancer: a prospective analysis and a meta-analysis
    Song, Fengju
    Qureshi, Abrar A.
    Gao, Xiang
    Li, Tricia
    Han, Jiali
    [J]. INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 2012, 41 (06) : 1694 - 1705
  • [52] 210Pb AND 210Po CONCENTRATIONS IN ITALIAN CIGARETTES AND EFFECTIVE DOSE EVALUATION
    Taroni, Mattia
    Zaga, Vincenzo
    Bartolomei, Paolo
    Gattavecchia, Enrico
    Pacifici, Roberta
    Zuccaro, Piergiorgio
    Esposito, Massimo
    [J]. HEALTH PHYSICS, 2014, 107 (03): : 195 - 199
  • [53] Competing risk bias to explain the inverse relationship between smoking and malignant melanoma
    Thompson, Caroline A.
    Zhang, Zuo-Feng
    Arah, Onyebuchi A.
    [J]. EUROPEAN JOURNAL OF EPIDEMIOLOGY, 2013, 28 (07) : 557 - 567
  • [54] Genetics and biology of vitamin D receptor polymorphisms
    Uitterlinden, AG
    Fang, Y
    van Meurs, JBJ
    Pols, HAP
    van Leeuwen, JPTM
    [J]. GENE, 2004, 338 (02) : 143 - 156
  • [55] Veierod MB, 1997, INT J CANCER, V71, P600, DOI 10.1002/(SICI)1097-0215(19970516)71:4<600::AID-IJC15>3.0.CO
  • [56] 2-F
  • [57] WINTERS TH, 1982, NEW ENGL J MED, V306, P364
  • [58] 1α,25-dihydroxyvitamin D3 inhibits in vitro invasiveness through the extracellular matrix and in vivo pulmonary metastasis of B16 mouse melanoma
    Yudoh, K
    Matsuno, H
    Kimura, T
    [J]. JOURNAL OF LABORATORY AND CLINICAL MEDICINE, 1999, 133 (02): : 120 - 128
  • [59] Melanoma risk is associated with vitamin D receptor gene polymorphisms
    Zeljic, Katarina
    Kandolf-Sekulovic, Lidija
    Supic, Gordana
    Pejovic, Janko
    Novakovic, Marijan
    Mijuskovic, Zeljko
    Magic, Zvonko
    [J]. MELANOMA RESEARCH, 2014, 24 (03) : 273 - 279
  • [60] Polymorphisms in the vitamin D receptor (VDR) genes and skin cancer risk in European population: a meta-analysis
    Zhao, Xian-Zhi
    Yang, Bao-Hong
    Yu, Guo-Hua
    Liu, Shu-Zhen
    Yuan, Zhi-Yong
    [J]. ARCHIVES OF DERMATOLOGICAL RESEARCH, 2014, 306 (06) : 545 - 553