Merkel cell carcinoma:: a clinicopathological study of 11 cases

被引:51
|
作者
Acebo, E
Vidaurrazaga, N
Varas, C
Burgos-Bretones, JJ
Díaz-Pérez, JL
机构
[1] Hosp Cruces, Dept Dermatol, Baracaldo 48903, Vizcaya, Spain
[2] Hosp Cruces, Dept Pathol, Baracaldo 48903, Vizcaya, Spain
关键词
immunohistochemistry; Merkel cell carcinoma; pathology; prognosis;
D O I
10.1111/j.1468-3083.2005.01224.x
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Objective To report our 12-year experience with Merkel cell carcinomas (MCCs) from a clinical and pathological point of view. Subjects and setting Eleven MCCs were diagnosed at our institution between 1991 and 2002. Methods A retrospective clinical, histopathological and immunohistochemical study was performed. Age, gender, location, size, stage, treatment and follow-up data were collected. Histopathological pattern and immunohistochemical study with CAM 5.2, cytokeratin 20 (CK20), CK7, Ber EP4, neurofilaments, synaptophysin, chromogranin, S100 protein, p53 protein, CD117, leucocyte common antigen (LCA) and Ki-67 were accomplished. Results Six females and five males with a mean age of 82 years were identified. Tumours were located on the face (n = 6), extremities (n = 3) and trunk (n = 1). At diagnosis, one patient was in stage la, six in stage Ib, three in stage II and one in stage III. All but one patient experienced wide surgical excision of the turnout. Additional treatment consisted of lymph node dissection in two patients, radiotherapy in four patients and systemic chemotherapy in one patient. Local recurrence developed in five patients. Three patients died because of MCC after 14 months of follow-up. Intermediate-size round cell proliferation was found in all cases. Additional small-size-cell pattern and trabecular pattern were observed in seven and six cases, respectively. Eccrine and squamous cell differentiation were found in three cases. A dot-like paranuclear pattern was observed in all cases with CAM 5.2 and neurofilaments, and in 89% of cases with CK20. Seventy-five per cent of cases reacted with Ber EP4, chromogranin and synaptophysin, 70% with p53, 22% with S 100 protein, 55% with CD117 and none with LCA. Ki-67 was found in 75% of tumoral cells on average. Fifty per cent of MCCs reacted with CK7 and showed eccrine differentiation areas. Conclusions MCC is an aggressive neuroendocrine turnout of the elderly. Wide surgical excision is the recommended treatment. Lymph node dissection, adjuvant radiotherapy and chemotherapy decrease regional recurrences but have not been demonstrated to increase survival. Immunohistochemically, MCC is an epithelial turnout with neuroendocrine features.
引用
收藏
页码:546 / 551
页数:6
相关论文
共 50 条
  • [21] Clinical features and outcomes of Merkel cell carcinoma in 20 cats
    Sumi, A.
    Chambers, J. K.
    Doi, M.
    Kudo, T.
    Omachi, T.
    Uchida, K.
    VETERINARY AND COMPARATIVE ONCOLOGY, 2018, 16 (04) : 554 - 561
  • [22] Clinicopathological characteristics and prognosis of Merkel cell carcinoma: a single-center retrospective study in Korea
    Ik Jun Moon
    Hyungmin Na
    Hye Soo Cho
    Chong Hyun Won
    Sung Eun Chang
    Mi Woo Lee
    Woo Jin Lee
    Journal of Cancer Research and Clinical Oncology, 2023, 149 : 10065 - 10074
  • [23] Clinicopathological characteristics and prognosis of Merkel cell carcinoma: a single-center retrospective study in Korea
    Moon, Ik Jun
    Na, Hyungmin
    Cho, Hye Soo
    Won, Chong Hyun
    Chang, Sung Eun
    Lee, Mi Woo
    Lee, Woo Jin
    JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 2023, 149 (12) : 10065 - 10074
  • [24] Vascular changes in Merkel cell carcinoma based on a histopathological study of 92 cases
    Vazmitel, Marina
    Michal, Michal
    Shelekhova, Ksenia V.
    Sima, Radek
    Mukensnabl, Petr
    Kazakov, Dmitry V.
    AMERICAN JOURNAL OF DERMATOPATHOLOGY, 2008, 30 (02) : 106 - 111
  • [25] Merkel cell carcinoma: descriptive study of 24 cases (1993-2001)
    Benessahraoui, M
    Dalstein, V
    Lorchel, F
    Algros, MP
    Puzenat, E
    Louvat, P
    Hassam, B
    Humbert, PH
    Aubin, F
    REVUE DE MEDECINE INTERNE, 2003, 24 (09): : 560 - 568
  • [26] Clinical experience on eight cases of Merkel cell carcinoma
    Cirillo, F
    Buononato, M
    Lima, G
    Cafaro, I
    Alquati, P
    TUMORI, 2003, 89 (02) : 146 - 151
  • [27] Merkel cell carcinoma -: a retrospective analysis of 17 cases
    Hohaus, K
    Köstler, E
    Schönlebe, J
    Klemm, E
    Wollina, U
    JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, 2003, 17 (01) : 20 - 24
  • [28] Prospective study of Merkel cell polyomavirus and risk of Merkel cell carcinoma
    Faust, Helena
    Andersson, Kristin
    Ekstrom, Johanna
    Hortlund, Maria
    Robsahm, Trude Eid
    Dillner, Joakim
    INTERNATIONAL JOURNAL OF CANCER, 2014, 134 (04) : 844 - 848
  • [29] Multimodality management for 145 cases of Merkel cell carcinoma
    Tai, Patricia
    Yu, Edward
    Assouline, Avi
    Lian, Ji Dong
    Joseph, Kurian
    Miale, Thomas
    Krzisch, Claude
    MEDICAL ONCOLOGY, 2010, 27 (04) : 1260 - 1266
  • [30] Multimodality management for 145 cases of Merkel cell carcinoma
    Patricia Tai
    Edward Yu
    Avi Assouline
    Ji Dong Lian
    Kurian Joseph
    Thomas Miale
    Claude Krzisch
    Medical Oncology, 2010, 27 : 1260 - 1266