Human secondary somatosensory cortex is involved in the processing of somatosensory rare stimuli: An fMRI study

被引:97
作者
Chen, Tzu Ling [1 ]
Babiloni, Claudio [3 ,4 ]
Ferretti, Antonio [1 ,2 ]
Perrucci, Mauro Gianni [1 ]
Romani, Gian Luca [1 ,2 ]
Rossini, Paolo Maria [4 ,5 ]
Tartaro, Armando [1 ,2 ]
Del Gratta, Cosimo [1 ,2 ]
机构
[1] Univ G dAnnunzio, Dept Clin Sci & Bioimaging, Chieti, Italy
[2] Fdn Univ Gabriele Dannunzio, ITAB, Chieti, Italy
[3] Univ Foggia, Dept Biomed Sci, Foggia, Italy
[4] Isola Tiberina, Osp FBF, Dip Neurosci, AFaR, Rome, Italy
[5] Clin Neurol Univ, Rome, Italy
关键词
fMRI; attention; somatosensory; electrical stimulation; oddball;
D O I
10.1016/j.neuroimage.2008.01.020
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
In the human somatosensory system, the contralateral primary somatosensory cortex (SI) is presumed to process and encode type and intensity of the sensory inputs, whereas the bilateral secondary somatosensory cortex (SII) is believed to perform higher order functions including sensorimotor integration, integration of information from the two body halves, attention, learning and memory. In this fMRI study we investigated the effect of attention on the activation of SI and SII, as induced by nonpainful and painful rare deviant electric stimuli during somatosensory oddball tasks. The working hypothesis is of stronger effects of attention on SII with respect to SI. Four runs were acquired according to an oddball scheme. Frequent nonpainful electrical stimuli were delivered to the ulnar nerve at motor threshold, whereas rare/deviant stimuli were delivered to median nerve in four conditions (one condition per run): nonpainful, painful, counting nonpainful, and counting painful. Results showed a statistically significant fMRI activation in bilateral SII but not in contralateral SI when the rare/deviant median nerve stimuli were delivered at nonpainful and painful levels as well as at the two levels of attention considered (i.e., associated with counting and non-counting tasks). Furthermore, fMRI activation in SII did not differ across the different levels of stimulus intensity (nonpainful, painful) and attention (non-counting, counting). These results corroborate the notion that SII is the target of independent pathways for the processing and integration of nonpainful and painful somatosensory stimuli salient for further high-order elaborations. (C) 2008 Elsevier Inc. All rights reserved.
引用
收藏
页码:1765 / 1771
页数:7
相关论文
共 51 条
[1]   Functional magnetic resonance imaging of brain activity in the visual oddball task [J].
Ardekani, BA ;
Choi, SJ ;
Hossein-Zadeh, GA ;
Porjesz, B ;
Tanabe, JL ;
Lim, KO ;
Bilder, R ;
Helpern, JA ;
Begleiter, H .
COGNITIVE BRAIN RESEARCH, 2002, 14 (03) :347-356
[2]   Somatosensory cortex responses to median nerve stimulation: fMRI effects of current amplitude and selective attention [J].
Backes, WH ;
Mess, WH ;
van Kranen-Mastenbroek, V ;
Reulen, JPH .
CLINICAL NEUROPHYSIOLOGY, 2000, 111 (10) :1738-1744
[3]   Imaging how attention modulates pain in humans using functional MRI [J].
Bantick, SJ ;
Wise, RG ;
Ploghaus, A ;
Clare, S ;
Smith, SM ;
Tracey, I .
BRAIN, 2002, 125 :310-319
[4]   TOPOGRAPHICAL RELATIONS BETWEEN IPSILATERAL CORTICAL AFFERENTS AND CALLOSAL NEURONS IN THE 2ND SOMATIC SENSORY AREA OF CATS [J].
BARBARESI, P ;
MINELLI, A ;
MANZONI, T .
JOURNAL OF COMPARATIVE NEUROLOGY, 1994, 343 (04) :582-596
[5]   Painful stimuli evoke different stimulus-response functions in the amygdala, prefrontal, insula and somatosensory cortex:: a single-trial fMRI study [J].
Bornhövd, K ;
Quante, M ;
Glauche, V ;
Bromm, B ;
Weiller, C ;
Büchel, C .
BRAIN, 2002, 125 :1326-1336
[6]   Linear systems analysis of functional magnetic resonance imaging in human V1 [J].
Boynton, GM ;
Engel, SA ;
Glover, GH ;
Heeger, DJ .
JOURNAL OF NEUROSCIENCE, 1996, 16 (13) :4207-4221
[7]   fMRI of thermal pain: Effects of stimulus laterality and attention [J].
Brooks, JCW ;
Nurmikko, TJ ;
Bimson, WE ;
Singh, KD ;
Roberts, N .
NEUROIMAGE, 2002, 15 (02) :293-301
[8]   Statistical methods of estimation and inference for functional MR image analysis [J].
Bullmore, E ;
Brammer, M ;
Williams, SCR ;
Rabehesketh, S ;
Janot, N ;
David, A ;
Mellers, J ;
Howard, R ;
Sham, P .
MAGNETIC RESONANCE IN MEDICINE, 1996, 35 (02) :261-277
[9]   Tactile attention tasks enhance activation in somatosensory regions of parietal cortex: A positron emission tomography study [J].
Burton, H ;
Abend, NS ;
MacLeod, AMK ;
Sinclair, RJ ;
Snyder, AZ ;
Raichle, ME .
CEREBRAL CORTEX, 1999, 9 (07) :662-674
[10]   Temporal and spatial dynamics of human forebrain activity during heat pain: Analysis by positron emission tomography [J].
Casey, KL ;
Morrow, TJ ;
Lorenz, J ;
Minoshima, S .
JOURNAL OF NEUROPHYSIOLOGY, 2001, 85 (02) :951-959