Clinical Applications of DNA Vaccines: Current Progress

被引：263

作者：

Ferraro, Bernadette ^{[1
]}

Morrow, Matthew P. ^{[1
]}

Hutnick, Natalie A. ^{[1
]}

Shin, Thomas H. ^{[1
]}

Lucke, Colleen E. ^{[1
]}

Weiner, David B. ^{[1
]}

机构：

[1] Univ Penn, Sch Med, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA

来源：

CLINICAL INFECTIOUS DISEASES | 2011年 / 53卷 / 03期

基金：

美国国家卫生研究院;

关键词：

CERVICAL INTRAEPITHELIAL NEOPLASIA; IN-VIVO ELECTROPORATION; GM-CSF DNA; PLASMID DNA; IMMUNE-RESPONSES; RHESUS MACAQUES; HIV-1; VACCINE; DOUBLE-BLIND; PHASE-I; VIRUS;

D O I：

10.1093/cid/cir334

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

It was discovered almost 20 years ago that plasmid DNA, when injected into the skin or muscle of mice, could induce immune responses to encoded antigens. Since that time, there has since been much progress in understanding the basic biology behind this deceptively simple vaccine platform and much technological advancement to enhance immune potency. Among these advancements are improved formulations and improved physical methods of delivery, which increase the uptake of vaccine plasmids by cells; optimization of vaccine vectors and encoded antigens; and the development of novel formulations and adjuvants to augment and direct the host immune response. The ability of the current, or second-generation, DNA vaccines to induce more-potent cellular and humoral responses opens up this platform to be examined in both preventative and therapeutic arenas. This review focuses on these advances and discusses both preventive and immunotherapeutic clinical applications.

引用

页码：296 / 302

页数：7

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