Value of Contrast-Enhanced Ultrasound for Evaluation of Cervical Lymph Node Metastasis in Papillary Thyroid Carcinoma

被引:23
作者
Fang, Fengkai [1 ]
Gong, Yi [2 ]
Liao, Liyan [3 ]
Ye, Fei [2 ]
Zuo, Zhongkun [2 ]
Li, Xiaodu [1 ]
Zhang, Qi [1 ]
Tang, Kui [1 ]
Xu, Yan [1 ]
Zhang, Rongsen [1 ]
Chen, Sijie [1 ]
Niu, Chengcheng [1 ]
机构
[1] Cent South Univ, Xiangya Hosp 2, Dept Ultrasound Diag, Changsha, Peoples R China
[2] Cent South Univ, Xiangya Hosp 2, Dept Thyroid Surg, Changsha, Peoples R China
[3] Cent South Univ, Xiangya Hosp 2, Dept Pathol, Changsha, Peoples R China
基金
中国国家自然科学基金;
关键词
contrast-enhanced ultrasound; conventional ultrasound; cervical lymph node metastasis; papillary thyroid carcinomas; benign cervical lymph nodes; DIAGNOSIS;
D O I
10.3389/fendo.2022.812475
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The aim of the study was to evaluate the diagnostic value of contrast-enhanced ultrasound (CEUS) in distinguishing between benign and malignant cervical lymph nodes (LNs) in patients with papillary thyroid carcinoma (PTC). Two hundred and one cervical LNs (157 metastatic from PTC and 44 benign) were evaluated using conventional ultrasonography (US) and CEUS before biopsy or surgery. Histopathology was used as the gold standard. We evaluated the size, long axis/short axis ratio (L/S), fatty hilum, hyper-echogenicity, calcification, cystic change, peripheral vascularity and CEUS parameters for each lymph nodule. The CEUS parameters included enhancement type, homogeneity, perfusion type, ring enhancement, peak intensity (PI) index and area under the curve (AUC) index. Univariate analysis demonstrated that compared with benign LNs, malignant LNs more frequently had L/S < 2, absence of a fatty hilum, presence of hyper-echogenicity, presence of calcification, peripheral vascularity, hyper-enhancement, heterogeneous enhancement, centripetal perfusion, ring enhancement, PI index > 1 and AUC index > 1 on preoperative US and CEUS. Binary logistic regression analysis demonstrated that hyper-enhancement, centripetal perfusion, and ring enhancement are independent CEUS characteristics related to malignant LNs for their differentiation from benign LNs (all p < 0.05). Our study indicated that preoperative CEUS characteristics may serve as a useful tool to identify malignant cervical LNs from benign cervical LNs.
引用
收藏
页数:9
相关论文
共 25 条
[1]   CONVENTIONAL ULTRASOUND, IMMUNOHISTOCHEMICAL FACTORS AND BRAFV600E MUTATION IN PREDICTING CENTRAL CERVICAL LYMPH NODE METASTASIS OF PAPILLARY THYROID CARCINOMA [J].
Chen, Jie ;
Li, Xiao-Long ;
Zhao, Chong-Ke ;
Wang, Dan ;
Wang, Qiao ;
Li, Ming-Xu ;
Wei, Qing ;
Ji, Guo ;
Xu, Hui-Xiong .
ULTRASOUND IN MEDICINE AND BIOLOGY, 2018, 44 (11) :2296-2306
[2]   Value of Qualitative and Quantitative Contrast-Enhanced Ultrasound Analysis in Preoperative Diagnosis of Cervical Lymph Node Metastasis From Papillary Thyroid Carcinoma [J].
Chen, Lei ;
Chen, Luzeng ;
Liu, Jinghua ;
Wang, Bin ;
Zhang, Hui .
JOURNAL OF ULTRASOUND IN MEDICINE, 2020, 39 (01) :73-81
[3]   Sonographic Characteristics of Papillary Thyroid Carcinoma With Coexistent Hashimoto's Thyroiditis in the Preoperative Prediction of Central Lymph Node Metastasis [J].
Chen, Sijie ;
Niu, Chengcheng ;
Peng, Qinghai ;
Tang, Kui .
FRONTIERS IN ENDOCRINOLOGY, 2021, 12
[4]   Imaging of perfusion using ultrasound [J].
Cosgrove, David ;
Lassau, Nathalie .
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2010, 37 :S65-S85
[5]   Diagnostic Value of Contrast-Enhanced Ultrasonography and Time-Intensity Curve in Differential Diagnosis of Cervical Metastatic and Tuberculous Lymph Nodes [J].
Cui, Qiu-li ;
Yin, Shan-shan ;
Fan, Zhi-Hui ;
Yang, Wei ;
Wang, Song ;
Yan, Kun .
JOURNAL OF ULTRASOUND IN MEDICINE, 2018, 37 (01) :83-92
[6]   2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer [J].
Haugen, Bryan R. ;
Alexander, Erik K. ;
Bible, Keith C. ;
Doherty, Gerard M. ;
Mandel, Susan J. ;
Nikiforov, Yuri E. ;
Pacini, Furio ;
Randolph, Gregory W. ;
Sawka, Anna M. ;
Schlumberger, Martin ;
Schuff, Kathryn G. ;
Sherman, Steven I. ;
Sosa, Julie Ann ;
Steward, David L. ;
Tuttle, R. Michael ;
Wartofsky, Leonard .
THYROID, 2016, 26 (01) :1-133
[7]   ROLE OF CONTRAST-ENHANCED ULTRASOUND IN THE PRE-OPERATIVE DIAGNOSIS OF CERVICAL LYMPH NODE METASTASIS IN PATIENTS WITH PAPILLARY THYROID CARCINOMA [J].
Hong, Yu-Rong ;
Luo, Zhi-Yan ;
Mo, Guo-Qiang ;
Wang, Ping ;
Ye, Qin ;
Huang, Pin-Tong .
ULTRASOUND IN MEDICINE AND BIOLOGY, 2017, 43 (11) :2567-2575
[8]   Prognosis of Patients with Papillary Thyroid Carcinoma Showing Postoperative Recurrence to the Central Neck [J].
Ito, Yasuhiro ;
Higashiyama, Takuya ;
Takamura, Yuuki ;
Kobayashi, Kaoru ;
Miya, Akihiro ;
Miyauchi, Akira .
WORLD JOURNAL OF SURGERY, 2011, 35 (04) :767-772
[9]   Preoperative High-Resolution Ultrasound for the Assessment of Malignant Central Compartment Lymph Nodes in Papillary Thyroid Cancer [J].
Khokhar, Mamoona T. ;
Day, Kristopher M. ;
Sangal, Rohit B. ;
Ahmedli, Nigar N. ;
Pisharodi, Latha R. ;
Beland, Michael D. ;
Monchik, Jack M. .
THYROID, 2015, 25 (12) :1351-1354
[10]   2013 European Thyroid Association Guidelines for Cervical Ultrasound Scan and Ultrasound-Guided Techniques in the Postoperative Management of Patients with Thyroid Cancer [J].
Leenhardt, L. ;
Erdogan, M. F. ;
Hegedus, L. ;
Mandel, S. J. ;
Paschke, R. ;
Rago, T. ;
Russ, G. .
EUROPEAN THYROID JOURNAL, 2013, 2 (03) :147-159