Characterization of thalidomide using Raman spectroscopy

被引：13

作者：

Cipriani, Penelope ^{[1
]}

Smith, Candace Y. ^{[1
]}

机构：

[1] Spelman Coll, Dept Chem, Atlanta, GA 30314 USA

来源：

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY | 2008年 / 69卷 / 02期

关键词：

Raman; thalidomide; anticancer; frequency; DFT;

D O I：

10.1016/j.saa.2007.04.002

中图分类号：

O433 [光谱学];

学科分类号：

0703 ; 070302 ;

摘要：

Thalidomide is a potent anticancer therapeutic drug whose mechanism of action has not yet been elucidated. In this report, experimental Raman spectroscopy is used to determine and characterize the vibrational frequencies of the drug. These normal modes are then compared to their quantum mechanical counterparts, which have been computed using density functional theory. Upon analysis of the spectra, we found that there was a high level of agreement between the wavenumbers. As such, this spectroscopic technique may be a viable tool for examining the way in which this drug interacts with its target molecules. (C) 2007 Published by Elsevier B.V.

引用

页码：333 / 337

页数：5

共 32 条

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