Endometrial LGR7 expression during menstrual cycle

被引：21

作者：

Campitiello, Maria Rosaria ^{[1
]}

De Franciscis, Pasquale ^{[1
]}

Mele, Daniela ^{[1
]}

Izzo, Gaia ^{[2
]}

Sinisi, Antonio ^{[3
]}

Delrio, Giovanni ^{[2
]}

Colacurci, Nicola ^{[1
]}

机构：

[1] Univ Naples 2, Dept Obstet Gynecol & Reprod Sci, Naples, Italy

[2] Univ Naples 2, Dept Expt Med F Bottazzi, Naples, Italy

[3] Univ Naples 2, Dept Clin & Expt Med & Surg, Endocrinol & Med Androl Sect, Naples, Italy

来源：

FERTILITY AND STERILITY | 2011年 / 95卷 / 08期

关键词：

Relaxin receptor; LGR7; human endometrium; implantation; endometrial receptivity; RELAXIN RECEPTOR LGR7; PERIIMPLANTATION PERIOD; MARMOSET MONKEY; SECRETORY PHASE; IN-VITRO; HORMONE; PREGNANCY; PATTERN; GROWTH; CELLS;

D O I：

10.1016/j.fertnstert.2011.01.124

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

In a prospective observational study, 50 healthy patients aged 18-39 years, with regular ovulatory cycle and normal hormone levels, underwent endometrial biopsy in the proliferative and secretory phase of the menstrual cycle for semiquantitative reverse-transcription polymerase chain reaction analysis of mRNA for LGR7, the classic relaxin receptor. LGR7 is constitutively expressed in human endometrium, and an increased LGR7 immunostaining is demonstrated in the secretory phase, confirming the involvement of relaxin in the physiology of endometrium and suggesting its role in implantation. (Fertil Steril (R) 2011; 95: 2511-4. (c) 2011 by American Society for Reproductive Medicine.)

引用

页码：2511 / 2514

页数：4

共 28 条

[1] Relaxin: A pleiotropic hormone [J].

Bani, D .

GENERAL PHARMACOLOGY-THE VASCULAR SYSTEM, 1997, 28 (01) :13-22

[2]

BANI D, 1995, LAB INVEST, V73, P709

[3] EFFECTS OF RELAXIN ON THE ENDOMETRIAL STROMA - STUDIES IN MICE [J].

BANI, G ;

MAURIZI, M ;

BIGAZZI, M ;

SACCHI, TB .

BIOLOGY OF REPRODUCTION, 1995, 53 (02) :253-262

[4] Increased expression of the relaxin receptor (LGR7) in human endometrium during the secretory phase of the menstrual cycle [J].

Bond, CP ;

Parry, LJ ;

Samuel, CS ;

Gehring, HM ;

Lederman, FL ;

Rogers, PAW ;

Summers, RJ .

RELAXIN AND RELATED PEPTIDES: FOURTH INTERNATIONAL CONFERENCE, 2005, 1041 :136-143

[5] Increased expression of the relaxin receptor (LGR7) in human endometrium during the secretory phase of the menstrual cycle [J].

Bond, CP ;

Parry, LJ ;

Samuel, CS ;

Gehring, HM ;

Lederman, FL ;

Rogers, PAW ;

Summers, RJ .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2004, 89 (07) :3477-3485

[6] SEQUENTIAL APPEARANCE OF RELAXIN, PROLACTIN AND IGFBP-1 DURING GROWTH AND DIFFERENTIATION OF THE HUMAN ENDOMETRIUM [J].

BRYANTGREENWOOD, GD ;

RUTANEN, EM ;

PARTANEN, S ;

COELHO, TK ;

YAMAMOTO, SY .

MOLECULAR AND CELLULAR ENDOCRINOLOGY, 1993, 95 (1-2) :23-29

[7] RELAXIN IN THE PREGNANT BABOON - EVIDENCE FOR LOCAL PRODUCTION IN REPRODUCTIVE TISSUES [J].

CASTRACANE, VD ;

LESSING, J ;

BRENNER, S ;

WEISS, G .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1985, 60 (01) :133-136

[8] Relaxin and prostaglandin E2 regulate interleukin 11 during human endometrial stromal cell decidualization [J].

Dimitriadis, E ;

Stoikos, C ;

Baca, M ;

Fairlie, WD ;

McCoubrie, JE ;

Salamonsen, LA .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2005, 90 (06) :3458-3465

[9] Relaxin in the marmoset monkey: Secretion pattern in the ovarian cycle and early pregnancy [J].

Einspanier, A ;

Nubbemeyer, R ;

Schlote, S ;

Schumacher, M ;

Ivell, R ;

Fuhrmann, K ;

Marten, A .

BIOLOGY OF REPRODUCTION, 1999, 61 (02) :512-520

[10] Characterization of relaxin binding in the uterus of the marmoset monkey [J].

Einspanier, A ;

Müller, D ;

Lubberstedt, J ;

Bartsch, O ;

Jurdzinski, A ;

Fuhrmann, K ;

Ivell, R .

MOLECULAR HUMAN REPRODUCTION, 2001, 7 (10) :963-970

← 1 2 3 →