Moderate exercise training does not worsen left ventricle remodeling and function in untreated severe hypertensive rats

被引:31
作者
Boissiere, Julien [1 ]
Eder, Veronique [1 ]
Machet, Marie-Christine [1 ]
Courteix, Daniel [2 ]
Bonnet, Pierre [1 ]
机构
[1] Univ Tours, Lab Phytopathol Paroi Arterielle, EA 3852, UFR Med, F-37032 Tours 1, France
[2] Univ Clermont Ferrand, Lab Interuniv Biol Activ Phys & Sport, F-63006 Clermont Ferrand, France
关键词
renal hypertension; cardiac function;
D O I
10.1152/japplphysiol.00442.2007
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Exercise training and hypertension induced cardiac hypertrophy but modulate differently left ventricle (LV) function. This study set out to evaluate cardiac adaptations induced by moderate exercise training in normotensive and untreated severe hypertensive rats. Four groups of animals were studied: normotensive (Ctl) and severe hypertensive (HT) Wistar rats were assigned to be sedentary (Sed) or perform a moderate exercise training (Ex) over a 10-wk period. Severe hypertension was induced in rat by a two-kidney, one-clip model. At the end of the training period, hemodynamic parameters and LV morphology and function were assessed using catheterism and conventional pulsed Doppler echocardiography. LV histology was performed to study fibrosis infiltrations. Severe hypertension increased systolic blood pressure to 202 +/- 9 mmHg and induced pathological hypertrophy (LV hypertrophy index was 0.34 +/- 0.02 vs. 0.44 +/- 0.02 in Ctl-Sed and HT-Sed groups, respectively) with LV relaxation alteration (early-to-atrial wave ratio = 2.02 +/- 0.11 vs. 1.63 +/- 0.12). Blood pressure was not altered by exercise training, but arterial stiffness was reduced in trained hypertensive rats (pulse pressure was 75 +/- 7 vs. 62 +/- 3 mmHg in HT-Sed and HT-Ex groups, respectively). Exercise training induced eccentric hypertrophy in both Ex groups by increasing LV cavity without alteration of LV systolic function. However, LV hypertrophy index was significantly decreased in normotensive rats only (0.34 +/- 0.02 vs. 0.30 +/- 0.02 in Ctl-Sed and Ctl-Ex groups, respectively). Moreover, exercise training improved LV passive filling in Ctl-Ex rats but not in Ht-Ex rats. In this study, exercise training did not reduce blood pressure and induced an additional physiological hypertrophy in untreated HT rats, which was slightly blunted when compared with Ctl rats. However, cardiac function was not worsened by exercise training.
引用
收藏
页码:321 / 327
页数:7
相关论文
共 32 条
[11]  
Hayashi A, 2000, J NUTR SCI VITAMINOL, V46, P165
[12]  
JUNIOR HM, 1995, COMP BIOCH PHYSL A, V112, P313
[13]   Spontaneous running increases aortic compliance in Wistar-Kyoto rats [J].
Kingwell, BA ;
Arnold, PJ ;
Jennings, GL ;
Dart, AM .
CARDIOVASCULAR RESEARCH, 1997, 35 (01) :132-137
[14]   EFFECTS OF REGULAR EXERCISE ON BLOOD-PRESSURE AND LEFT-VENTRICULAR HYPERTROPHY IN AFRICAN-AMERICAN MEN WITH SEVERE HYPERTENSION [J].
KOKKINOS, PF ;
NARAYAN, P ;
COLLERAN, JA ;
PITTARAS, A ;
NOTARGIACOMO, A ;
REDA, D ;
PAPADEMETRIOU, V .
NEW ENGLAND JOURNAL OF MEDICINE, 1995, 333 (22) :1462-1467
[15]   PLASMA-RENIN AND SODIUM BALANCE DURING DEVELOPMENT OF MODERATE AND SEVERE RENAL-HYPERTENSION IN RATS [J].
LEENEN, FHH ;
DEJONG, W .
CIRCULATION RESEARCH, 1975, 36 (06) :179-186
[16]   SERIAL ECHOCARDIOGRAPHIC-DOPPLER ASSESSMENT OF LEFT-VENTRICULAR GEOMETRY AND FUNCTION IN RATS WITH PRESSURE-OVERLOAD HYPERTROPHY - CHRONIC ANGIOTENSIN-CONVERTING ENZYME-INHIBITION ATTENUATES THE TRANSITION TO HEART-FAILURE [J].
LITWIN, SE ;
KATZ, SE ;
WEINBERG, EO ;
LORELL, BH ;
AURIGEMMA, GP ;
DOUGLAS, PS .
CIRCULATION, 1995, 91 (10) :2642-2654
[17]   EXERCISE TRAINING AND ITS EFFECTS WITH RENAL HYPERTENSIVE RATS [J].
MARCUS, KD ;
TIPTON, CM .
JOURNAL OF APPLIED PHYSIOLOGY, 1985, 59 (05) :1410-1415
[18]  
Melo RM, 2003, HYPERTENSION, V42, P851, DOI 10.1161/01.HYP.0000086201.27420.33
[19]   Diastolic function in various forms of left ventricular hypertrophy: Contribution of active Doppler stress echo [J].
Mockel, M ;
Stork, T .
INTERNATIONAL JOURNAL OF SPORTS MEDICINE, 1996, 17 :S184-S190
[20]   Renal hypertension prevents run training modification of cardiomyocyte diastolic Ca2+ regulation in male rats [J].
Palmer, BM ;
Lynch, JM ;
Snyder, SM ;
Moore, RL .
JOURNAL OF APPLIED PHYSIOLOGY, 2001, 90 (06) :2063-2069