Effect of stomach motility on food hydrolysis and gastric emptying: Insight from computational models

被引：8
作者：
Kuhar, Sharun [1 ]
Lee, Jae Ho [1 ,2 ,5 ]
Seo, Jung-Hee [1 ,2 ]
Pasricha, Pankaj J. [3 ]
Mittal, Rajat [1 ,2 ,4 ]
机构：
[1] Johns Hopkins Univ, Dept Mech Engn, Baltimore, MD 21218 USA
[2] Johns Hopkins Univ, Inst Computat Med, Baltimore, MD 21218 USA
[3] Johns Hopkins Sch Med, Div Gastroenterol & Hepatol, Baltimore, MD 21205 USA
[4] Johns Hopkins Sch Med, Dept Med, Baltimore, MD 21205 USA
[5] US FDA, Ctr Drug Evaluat & Res, Silver Spring, MD 20903 USA
来源：
PHYSICS OF FLUIDS | 2022年 / 34卷 / 11期
基金：
美国国家卫生研究院; 美国国家科学基金会;
关键词：
DIGESTION; MEAL; TRENDS; DISINTEGRATION; ERYTHROMYCIN; MECHANISMS; GENERATION; PHYSIOLOGY; HUMANS; TIME;
D O I：
10.1063/5.0120933
中图分类号：
O3 [力学];
学科分类号：
08 ; 0801 ;
摘要：
The peristaltic motion of stomach walls combines with the secretion of digestive enzymes to initiate the process that breaks down food. In this study, the mixing, breakdown, and emptying of a liquid meal containing protein is simulated in a model of a human stomach. In this model, pepsin, the gastric enzyme responsible for protein hydrolysis, is secreted from the proximal region of the stomach walls and allowed to react with the contents of the stomach. The velocities of the retropulsive jet induced by the peristaltic motion, the emptying rate, and the extent of hydrolysis are quantified for a control case as well as for three other cases with reduced motility of the stomach, which may result from conditions such as diabetes mellitus. This study quantifies the effect of stomach motility on the rate of food breakdown and its emptying into the duodenum and we correlate these observations with the mixing in the stomach induced by the wall motion.
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页数：17
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