Immunologic Biomarkers, Morbidity, and Mortality in Treated HIV Infection

被引：189

作者：

Hunt, Peter W. ^{[1
]}

Lee, Sulggi A. ^{[1
]}

Siedner, Mark J. ^{[2
,3
]}

机构：

[1] Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA

[2] Massachusetts Gen Hosp, Dept Med, Boston, MA 02114 USA

[3] Harvard Med Sch, Boston, MA USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2016年 / 214卷

基金：

美国国家卫生研究院;

关键词：

immune activation; inflammation; biomarkers; morbidity; mortality; HIV-1; infection; antiretroviral therapy; T-CELL-ACTIVATION; INITIATING ANTIRETROVIRAL THERAPY; IMMUNE ACTIVATION; PREDICT MORTALITY; MICROBIAL TRANSLOCATION; TRYPTOPHAN CATABOLISM; SYSTEMIC INFLAMMATION; MONOCYTE ACTIVATION; KYNURENINE PATHWAY; SOLUBLE CD14;

D O I：

10.1093/infdis/jiw275

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Despite marked improvements in the modern treatment era, human immunodeficiency virus (HIV)-infected individuals, particularly those who initiated antiretroviral therapy (ART) at advanced disease stages, continue to have increased age-related morbidity and mortality, compared with the general population. Immune activation and inflammation persist despite suppressive ART and predict many of these morbidities. The goal of this review is to examine the evidence suggesting a link between the persistent inflammatory state and morbidity and mortality in this setting, to describe the impact of early ART initiation on these factors, and to highlight important unanswered questions for the field. We also advance a hypothesis to explain why some morbidities-and their root inflammatory drivers-may be prevented more than others by early ART initiation.

引用

页码：S44 / S50

页数：7

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