Multi-site probe for selective turn-on fluorescent detection of Al(III) in aqueous solution: synthesis, cation binding, mode of coordination, logic gate and cell imaging

被引:14
作者
Mahalakshmi, G. [1 ]
Kumar, P. Saravana [1 ]
Vennila, K. N. [1 ]
Sivaraman, G. [1 ]
Seenivasaperumal, M. [1 ]
Elango, Kuppanagounder P. [1 ]
机构
[1] Gandhigram Rural Inst, Dept Chem, Gandhigram 624302, India
关键词
fluorescence; aluminium; cell imaging; logic gate; coordination; AL3+ IONS; CHEMOSENSOR; SENSOR; RECOGNITION; CU2+; FOOD;
D O I
10.1088/2050-6120/ab823e
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
An easy to make organic probe (hereafter called as R) possessing multiple ligating sites have been synthesized and characterized using spectral techniques. The probe exhibits selective and sensitive turn-on fluorescence response with Al(III) in aqueous dimethylformamide (DMF) (1:1 v/v) solution. Fluorescence titration experiment shows that the probe binds with Al(III) with a 1:1 stoichiometry and a binding constant of 6.6 x 10(4) M-1.The mode of coordination of R with Al(III) has been established suing Al-27 and H-1 NMR studies and the results suggest formation of an octahedral complex been them. The suggested point of attachment of R with Al(III) corroborates well with Density Functional Theory (DFT) optimized structure and Mulliken charges computed. Chelation-enhanced fluorescence (CHEF) is proposed as the mechanism of enhancement of fluorescence upon addition of Al(III) to R. The probe detects Al(III) in aqueous solution with a detection limit of 0.2 mu M, which is much lower than the permissible limit of Al(III) set by the World Health Organization (WHO).The probe works in a wide pH range (4-11) and thus makes it a suitable candidate for environmental and biological applications. The fluorescence signals of R were used to construct an INHIBIT molecular logic gate. The confocal fluorescence microscope experiments show that R could be employed as a fluorescent probe for detecting Al(III) in living cells.
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页数:11
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