Palladium-catalyzed C-H bond functionalization of C6-arylpurines

被引：55

作者：

Guo, Hai-Ming ^{[1
]}

Rao, Wei-Hao ^{[1
]}

Niu, Hong-Ying ^{[2
]}

Jiang, Li-Li ^{[1
]}

Meng, Ge ^{[1
]}

Jin, Jia-Jia ^{[1
]}

Yang, Xi-Ning ^{[1
]}

Qu, Gui-Rong ^{[1
]}

机构：

[1] Henan Normal Univ, Coll Chem & Environm Sci, Minist Educ, Key Lab Green Chem Media & React, Xinxiang 453007, Henan, Peoples R China

[2] Henan Inst Sci & Technol, Sch Chem & Chem Engn, Xinxiang 453003, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2011年 / 47卷 / 19期

关键词：

CROSS-COUPLING REACTIONS; PURINE NUCLEOSIDE DERIVATIVES; CARBON-HYDROGEN BONDS; REDUCTIVE ELIMINATION; CYTOSTATIC ACTIVITY; EFFICIENT SYNTHESIS; ACTIVATION; ALKYLATION; MECHANISM; REAGENTS;

D O I：

10.1039/c1cc11135c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A highly regioselective Pd-catalyzed C(Ar)-H bond activation method was developed for the modification of purines (nucleosides) with different functional groups by using purine as a directing group. This approach provides a new access to a variety of functionalized purines (nucleosides) which are potentially of great importance in medicinal chemistry.

引用

页码：5608 / 5610

页数：3

共 54 条

[11] Palladium(II)-Catalyzed C-H Activation/C-C Cross-Coupling Reactions: Versatility and Practicality
Chen, Xiao
Engle, Keary M.
Wang, Dong-Hui
Yu, Jin-Quan
[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2009, 48 (28) : 5094 - 5115
[12] PyDipSi: A General and Easily Modifiable/Traceless Si-Tethered Directing Group for C-H Acyloxylation of Arenes
Chernyak, Natalia
Dudnik, Alexander S.
Huang, Chunhui
Gevorgyan, Vladimir
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2010, 132 (24) : 8270 - +
[13] Rhodium-Catalyzed C-C Bond Formation via Heteroatom-Directed C-H Bond Activation
Colby, Denise A.
Bergman, Robert G.
Ellman, Jonathan A.
[J]. CHEMICAL REVIEWS, 2010, 110 (02) : 624 - 655
[14] Introduction to Selective Functionalization of C-H Bonds
Crabtree, Robert H.
[J]. CHEMICAL REVIEWS, 2010, 110 (02) : 575 - 575
[15] Palladium- and Copper-Catalyzed Arylation of Carbon-Hydrogen Bonds
Daugulis, Olafs
Do, Hien-Quang
Shabashov, Dmitry
[J]. ACCOUNTS OF CHEMICAL RESEARCH, 2009, 42 (08) : 1074 - 1086
[16] A highly selective catalytic method for the oxidative functionalization of C-H bonds
Dick, AR
Hull, KL
Sanford, MS
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2004, 126 (08) : 2300 - 2301
[17] Highly efficient Suzuki-Miyaura coupling of heterocyclic substrates through rational reaction design
Fleckenstein, Christoph A.
Plenio, Herbert
[J]. CHEMISTRY-A EUROPEAN JOURNAL, 2008, 14 (14) : 4267 - 4279
[18] Iron-catalyzed cross-coupling reactions
Fürstner, A
Leitner, A
Méndez, M
Krause, H
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2002, 124 (46) : 13856 - 13863
[19] Converting gem-dimethyl groups into cyclopropanes via Pd-catalyzed sequential C-H activation and radical cyclization
Giri, Ramesh
Wasa, Masayuki
Breazzano, Steven P.
Yu, Jin-Quan
[J]. ORGANIC LETTERS, 2006, 8 (25) : 5685 - 5688
[20] Pd-catalyzed amination of nucleoside arylsulfonates to yield N6-aryl-2,6-diaminopurine nucleosides
Gunda, P
Russon, LM
Lakshman, MK
[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2004, 43 (46) : 6372 - 6377

← 1 2 3 4 5 6 →