Palladium-catalyzed C-H bond functionalization of C6-arylpurines

被引：55

作者：

Guo, Hai-Ming ^{[1
]}

Rao, Wei-Hao ^{[1
]}

Niu, Hong-Ying ^{[2
]}

Jiang, Li-Li ^{[1
]}

Meng, Ge ^{[1
]}

Jin, Jia-Jia ^{[1
]}

Yang, Xi-Ning ^{[1
]}

Qu, Gui-Rong ^{[1
]}

机构：

[1] Henan Normal Univ, Coll Chem & Environm Sci, Minist Educ, Key Lab Green Chem Media & React, Xinxiang 453007, Henan, Peoples R China

[2] Henan Inst Sci & Technol, Sch Chem & Chem Engn, Xinxiang 453003, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2011年 / 47卷 / 19期

关键词：

CROSS-COUPLING REACTIONS; PURINE NUCLEOSIDE DERIVATIVES; CARBON-HYDROGEN BONDS; REDUCTIVE ELIMINATION; CYTOSTATIC ACTIVITY; EFFICIENT SYNTHESIS; ACTIVATION; ALKYLATION; MECHANISM; REAGENTS;

D O I：

10.1039/c1cc11135c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A highly regioselective Pd-catalyzed C(Ar)-H bond activation method was developed for the modification of purines (nucleosides) with different functional groups by using purine as a directing group. This approach provides a new access to a variety of functionalized purines (nucleosides) which are potentially of great importance in medicinal chemistry.

引用

页码：5608 / 5610

页数：3

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