ESR Studies of Paramagnetic Centers in Pharmaceutical Materials - Cefaclor and Clarithromycin as an Example

被引：15

作者：

Skowronska, A. ^{[2
]}

Wojciechowski, M. ^{[2
]}

Ramos, P. ^{[3
]}

Pilawa, B. ^{[3
]}

Kruk, D. ^{[1
]}

机构：

[1] Univ Warmia & Mazury Olsztyn, Fac Math & Comp Sci, PL-10710 Olsztyn, Poland

[2] Jagiellonian Univ, Inst Phys, PL-30059 Krakow, Poland

[3] Med Univ Silesia, Dept Biophys, Sosnowiec, Poland

来源：

ACTA PHYSICA POLONICA A | 2012年 / 121卷 / 02期

关键词：

D O I：

10.12693/APhysPolA.121.514

中图分类号：

O4 [物理学];

学科分类号：

0702 ;

摘要：

Electron spin resonance (ESR) studies of two antibiotics, Cefaclor and Clarithromycin, have been performed in order to investigate concentration and dynamics of free radicals generated in these compounds due to thermal sterilization. For Cefaclor three combinations of temperature and heating time have been applied: 160 degrees C, 170 degrees C, 180 degrees C for 120 min, 60 min, and 30 min, respectively, according to the pharmaceutical sterilization norm. Clarithromycin has been heated at 160 degrees C for 120 min. The ESR lineshape has been investigated versus microwave power ranging from 2.2 mW to 70 mW. Electron spin-spin relaxation time has been estimated from the ESR lineshape analysis. Concentrations of radicals generated due to different sterilization procedures have been compared with the purpose to select the best sterilization scheme.

引用

页码：514 / 517

页数：4