How stereochemistry affects the physicochemical features of gemini surfactant based cationic liposomes

被引：21
作者：
Aleandri, Simone [2 ]
Bonicelli, Maria Grazia [3 ]
Bordi, Federico [4 ,5 ]
Casciardi, Stefano [6 ]
Diociaiuti, Marco [7 ]
Giansanti, Luisa [1 ,2 ]
Leonelli, Francesca [2 ]
Mancini, Giovanna [1 ,2 ]
Perrone, Giuseppe [3 ]
Sennato, Simona [4 ,5 ]
机构：
[1] Univ Roma La Sapienza, CNR, Ist Metodol Chim, I-00185 Rome, Italy
[2] Univ Roma La Sapienza, Dipartimento Chim, I-00185 Rome, Italy
[3] Univ Roma La Sapienza, Dipartimento Ingn Chim, I-00185 Rome, Italy
[4] Univ Roma La Sapienza, Dipartimento Fis, I-00185 Rome, Italy
[5] Univ Roma La Sapienza, CNR IPCF, I-00185 Rome, Italy
[6] INAIL Ex ISPESL, Dipartimento Igiene Lavoro, I-00040 Monte Porzio Catone, Italy
[7] Ist Super Sanita, Dipartimento Tecnol & Salute, I-00161 Rome, Italy
来源：
SOFT MATTER | 2012年 / 8卷 / 21期
关键词：
PHOTODYNAMIC THERAPY; PHASE-TRANSITION; TRANSFECTION; LAURDAN; PHOTOSENSITIZER; MEMBRANES; EFFICIENT; VESICLES; SPACER; PROBE;
D O I：
10.1039/c2sm25193k
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
The physicochemical features of mixed cationic liposomes formulated with 1,2-dimyristoyl-sn-glycero-3-phosphatidylcoline and one of three stereomeric cationic gemini surfactants were investigated by differential scanning calorimetry, fluorescence, TEM and dynamic laser light scattering. Actually, it was shown that the different stereochemistry of these gemini can strongly influence their capability of condensing and transfecting a plasmid DNA and of delivering a photosensitizer. The results obtained in this investigation show that the stereochemistry of liposome components and their percentage in the formulation may have dramatic effects on the organization of the lipid bilayer and hence on the morphological and physicochemical features of vesicles, thus being highly relevant to the biological features evaluated previously.
引用
收藏
页码：5904 / 5915
页数：12
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