Association Between Circulating DNA, Serum (1→3)-β-D-Glucan, and Pulmonary Fungal Burden in Pneumocystis Pneumonia

被引：24

作者：

Costa, Jean-Marc ^{[1
,2
]}

Botterel, Francoise ^{[1
]}

Cabaret, Odile ^{[1
]}

Foulet, Francoise ^{[1
]}

Cordonnier, Catherine ^{[3
]}

Bretagne, Stephane ^{[1
,4
,5
]}

机构：

[1] Hop Henri Mondor, AP HP, Lab Parasitol Mycol, F-94010 Creteil, France

[2] Lab CERBA, Paris, France

[3] Univ Paris Est Creteil, Hop Henri Mondor, AP HP, Serv Hematol Clin, Paris, France

[4] Inst Pasteur, Ctr Natl Reference Mycol & Antifong, Unite Mycol Mol, Paris, France

[5] CNRS, URA 3012, Paris, France

来源：

CLINICAL INFECTIOUS DISEASES | 2012年 / 55卷 / 02期

关键词：

CARINII DNA; IMMUNOCOMPROMISED PATIENTS; PCR; DIAGNOSIS; BLOOD; INFECTIONS; SPECIMENS;

D O I：

10.1093/cid/cis412

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Circulating Pneumocystis jirovecii DNA and (1→3)-d-glucan determined in 70 serum samples from immunocompromised patients were compared to fungal load in bronchoalveolar lavage fluids assessed using quantitative polymerase chain reaction. Both serum biomarkers are influenced by pulmonary fungal load, which should be taken into account when diagnosing Pneumocystis infection. © 2012 The Author.

引用

页码：E5 / E8

页数：4

共 12 条

[1] DIAGNOSIS OF PNEUMOCYSTIS-CARINII PNEUMONIA IN AIDS PATIENTS BY USING POLYMERASE CHAIN-REACTIONS ON SERUM SPECIMENS [J].

ATZORI, C ;

LU, JJ ;

JIANG, BD ;

BARTLETT, MS ;

ORLANDO, G ;

QUEENER, SF ;

SMITH, JW ;

CARGNEL, A ;

LEE, CH .

JOURNAL OF INFECTIOUS DISEASES, 1995, 172 (06) :1623-1626

[2] Clinical Significance of Quantifying Pneumocystis jirovecii DNA by Using Real-Time PCR in Bronchoalveolar Lavage Fluid from Immunocompromised Patients [J].

Botterel, Francoise ;

Cabaret, Odile ;

Foulet, Francoise ;

Cordonnier, Catherine ;

Costa, Jean-Marc ;

Bretagne, Stephane .

JOURNAL OF CLINICAL MICROBIOLOGY, 2012, 50 (02) :227-231

[3]

Calderón EJ, 2010, EXPERT REV ANTI-INFE, V8, P683, DOI [10.1586/eri.10.42, 10.1586/eri.10.11, 10.1586/ERI.10.42]

[4] β-D-Glucan and S-adenosylmethionine serum levels for the diagnosis of Pneumocystis pneumonia in HIV-negative Patients: A prospective study [J].

de Boer, Mark G. J. ;

Gelinck, Luc B. S. ;

van Zelst, Bertrand D. ;

van de Sande, Wendy W. J. ;

Willems, Luuk N. A. ;

van Dissel, Jaap T. ;

de Jonge, Robert ;

Kroon, Frank P. .

JOURNAL OF INFECTION, 2011, 62 (01) :93-100

[5] Revised definitions of invasive fungal disease from the European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC/MSG) Consensus Group [J].

De Pauw, Ben ;

Walsh, Thomas J. ;

Donnelly, J. Peter ;

Stevens, David A. ;

Edwards, John E. ;

Calandra, Thierry ;

Pappas, Peter G. ;

Maertens, Johan ;

Lortholary, Olivier ;

Kauffman, Carol A. ;

Denning, David W. ;

Patterson, Thomas F. ;

Maschmeyer, Georg ;

Bille, Jacques ;

Dismukes, William E. ;

Herbrecht, Raoul ;

Hope, William W. ;

Kibbler, Christopher C. ;

Kullberg, Bart Jan ;

Marr, Kieren A. ;

Munoz, Patricia ;

Odds, Frank C. ;

Perfect, John R. ;

Restrepo, Angela ;

Ruhnke, Markus ;

Segal, Brahm H. ;

Sobel, Jack D. ;

Sorrell, Tania C. ;

Viscoli, Claudio ;

Wingard, John R. ;

Zaoutis, Theoklis ;

Bennett, John E. .

CLINICAL INFECTIOUS DISEASES, 2008, 46 (12) :1813-1821

[6] β-Glucan Antigenemia Assay for the Diagnosis of Invasive Fungal Infections in Patients With Hematological Malignancies: A Systematic Review and Meta-Analysis of Cohort Studies From the Third European Conference on Infections in Leukemia (ECIL-3) [J].

Lamoth, Frederic ;

Cruciani, Mario ;

Mengoli, Carlo ;

Castagnola, Elio ;

Lortholary, Olivier ;

Richardson, Malcolm ;

Marchetti, Oscar .

CLINICAL INFECTIOUS DISEASES, 2012, 54 (05) :633-643

[7] Detection of Pneumocystis carinii DNA in blood specimens from human immunodeficiency virus-infected patients by nested PCR [J].

Rabodonirina, M ;

Cotte, L ;

Boibieux, A ;

Kaiser, K ;

Mayençon, M ;

Raffenot, D ;

Trepo, C ;

Peyramond, D ;

Picot, S .

JOURNAL OF CLINICAL MICROBIOLOGY, 1999, 37 (01) :127-131

[8] USEFULNESS OF PCR FOR DETECTION OF PNEUMOCYSTIS-CARINII DNA [J].

ROUX, P ;

LAVRARD, I ;

POIROT, JL ;

CHOUAID, C ;

DENIS, M ;

OLIVIER, JL ;

NIGOU, M ;

MILTGEN, M .

JOURNAL OF CLINICAL MICROBIOLOGY, 1994, 32 (09) :2324-2326

[9] Blood (1→3)-β-D-Glucan as a Diagnostic Test for HIV-Related Pneumocystis jirovecii Pneumonia [J].

Sax, Paul E. ;

Komarow, Lauren ;

Finkelman, Malcolm A. ;

Grant, Philip M. ;

Andersen, Janet ;

Scully, Eileen ;

Powderly, William G. ;

Zolopa, Andrew R. .

CLINICAL INFECTIOUS DISEASES, 2011, 53 (02) :197-202

[10] APPLICATION OF DNA AMPLIFICATION TO PNEUMOCYSTOSIS - PRESENCE OF SERUM PNEUMOCYSTIS-CARINII DNA DURING HUMAN AND EXPERIMENTALLY INDUCED PNEUMOCYSTIS-CARINII PNEUMONIA [J].

SCHLUGER, N ;

GODWIN, T ;

SEPKOWITZ, K ;

ARMSTRONG, D ;

BERNARD, E ;

RIFKIN, M ;

CERAMI, A ;

BUCALA, R .

JOURNAL OF EXPERIMENTAL MEDICINE, 1992, 176 (05) :1327-1333

← 1 2 →