MicroRNA-125b promotes invasion and metastasis of gastric cancer by targeting STARD13 and NEU1

被引：39

作者：

Chang, Shuai ^{[1
]}

He, Shicai ^{[1
]}

Qiu, Guanglin ^{[1
]}

Lu, Jing ^{[1
]}

Wang, Jin ^{[1
]}

Liu, Junsong ^{[1
]}

Fan, Lin ^{[1
]}

Zhao, Wei ^{[1
]}

Che, Xiangming ^{[1
]}

机构：

[1] Xi An Jiao Tong Univ, Dept Gen Surg, Affiliated Hosp 1, 277 West Yanta Rd, Xian 710061, Shaanxi, Peoples R China

来源：

TUMOR BIOLOGY | 2016年 / 37卷 / 09期

基金：

中国国家自然科学基金;

关键词：

Gastric cancer; Metastasis; MicroRNA-125b; NEU1; STARD13; TUMOR-SUPPRESSOR; FOCAL ADHESIONS; POOR-PROGNOSIS; EXPRESSION; MIR-125B; PROFILES; CELLS; PROLIFERATION; PROGRESSION; SIGNATURES;

D O I：

10.1007/s13277-016-5094-y

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

MicroRNAs have been documented playing key roles in cancer development and progression. Here, we investigate the role of miR-125b in gastric cancer metastasis. We found that the expression of miR-125b was up-regulated in gastric cancer tissue specimens compared with their corresponding nontumorous tissues, and the up-regulated miR-125b level was significantly associated with TNM stage and lymph node-metastasis. Overexpression of miR-125b promoted gastric cancer cell migration and invasion in vitro and metastasis in vivo. STARD13 and NEU1 were identified as direct target genes of miR-125b by luciferase assays, and they were involved in the cell migration and invasion regulated by miR-125b in gastric cancer. Taken together, miR-125b functions as an oncogene in gastric cancer and represents a new potential therapeutic target for gastric cancer.

引用

页码：12141 / 12151

页数：11

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