Causal associations between risk factors and common diseases inferred from GWAS summary data

被引：645

作者：

Zhu, Zhihong ^{[1
]}

Zheng, Zhili ^{[1
,2
]}

Zhang, Futao ^{[1
]}

Wu, Yang ^{[1
]}

Trzaskowski, Maciej ^{[1
]}

Maier, Robert ^{[1
]}

Robinson, Matthew R. ^{[1
]}

McGrath, John J. ^{[3
,4
,5
]}

Visscher, Peter M. ^{[1
,3
]}

Wray, Naomi R. ^{[1
,3
]}

Yang, Jian ^{[1
,3
]}

机构：

[1] Univ Queensland, Inst Mol Biosci, Brisbane, Qld 4072, Australia

[2] Wenzhou Med Univ, Sch Ophthalmol & Optometry, Eye Hosp, Wenzhou 325027, Zhejiang, Peoples R China

[3] Univ Queensland, Queensland Brain Inst, Brisbane, Qld 4072, Australia

[4] Pk Ctr Mental Hlth, Queensland Ctr Mental Hlth Res, Wacol, Qld 4072, Australia

[5] Aarhus Univ, Natl Ctr Register Based Res, DK-8000 Aarhus C, Denmark

来源：

NATURE COMMUNICATIONS | 2018年 / 9卷

基金：

英国医学研究理事会; 新加坡国家研究基金会; 澳大利亚研究理事会;

关键词：

BODY-MASS INDEX; TYPE-2; DIABETES-MELLITUS; GENOME-WIDE ASSOCIATION; CORONARY-HEART-DISEASE; MENDELIAN RANDOMIZATION; MACULAR DEGENERATION; LIFE-STYLE; AGE; EPIDEMIOLOGY; INSTRUMENTS;

D O I：

10.1038/s41467-017-02317-2

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Health risk factors such as body mass index (BMI) and serum cholesterol are associated with many common diseases. It often remains unclear whether the risk factors are cause or consequence of disease, or whether the associations are the result of confounding. We develop and apply a method (called GSMR) that performs a multi-SNP Mendelian randomization analysis using summary-level data from genome-wide association studies to test the causal associations of BMI, waist-to-hip ratio, serum cholesterols, blood pressures, height, and years of schooling (EduYears) with common diseases (sample sizes of up to 405,072). We identify a number of causal associations including a protective effect of LDL-cholesterol against type-2 diabetes (T2D) that might explain the side effects of statins on T2D, a protective effect of EduYears against Alzheimer's disease, and bidirectional associations with opposite effects (e.g., higher BMI increases the risk of T2D but the effect of T2D on BMI is negative).

引用

页数：12

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